Patents Assigned to Thomas Jafferson University
  • Multimerization of HIV-1 vif protein as a therapeutic target
    Publication number: 20080167199
    Abstract: The HIV-1 protein Vif comprises a multimerization domain that allows Vif-Vif interaction and Vif multimerization, which is important for Vif function in the HIV-1 life-cycle. A method for screening for an antagonist of Vif comprises contacting the multimerization domain of Vif with a test compound that specifically binds the multimerization domain. Antagonists identified by the screening assay inhibit Vif multimerization. The antagonists inhibit essential functions of Vif and accordingly are useful as inhibitors of HIV-1 replication.
    Type: Application
    Filed: June 4, 2007
    Publication date: July 10, 2008
    Applicant: Thomas Jafferson University
    Inventors: Hui Zhang, Roger J. Pomerantz, Bin Yang