Patents Assigned to Thomas Jefferson University and Health System, Innovation Pillar
  • CTLA4-binding protein peptide-linker masks
    Patent number: 11926652
    Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: March 12, 2024
    Assignees: City of Hope, Thomas Jefferson University and Health System, Innovation Pillar
    Inventors: John Williams, Ulrich Rodeck, Miso Park, Kurt Jenkins
  • CTLA4-binding protein peptide-linker masks
    Patent number: 10689423
    Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: June 23, 2020
    Assignees: City of Hope, Thomas Jefferson University and Health System Innovation Pillar
    Inventors: John Williams, Ulrich Rodeck
  • CTLA4-BINDING PROTEIN PEPTIDE-LINKER MASKS
    Publication number: 20190169245
    Abstract: Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.
    Type: Application
    Filed: January 13, 2016
    Publication date: June 6, 2019
    Applicants: City of Hope, Thomas Jefferson University and Health System, Innovation Pillar
    Inventors: John WILLIAMS, Ulrich RODECK