Abstract: A quartering pill splitter includes a bed having a recess formed within, the recess having a cross section which substantially conforms to the pill shape. A thin, cruciate cutting blade assembly is disposed below the pill bed, so that the pill, when inserted into the recess, rests on the cutting edges of the cruciate cutting blade assembly. A plunger, containing an upper compression member is moveable with respect to the cutting blade assembly and is forceably engaged against the pill disposed in the bed recess when the user strikes the cap of the plunger, thus cutting the pill into quarters in a single stroke. The cruciate cutting blade assembly contains a first blade and a second blade at a right angle relative to the first blade, and which is offset from the first blade a distance equal to the thickness of the first blade.