Patents Assigned to Thrombinoscope B.V.
  • Method for determining the course of proteolytic activity
    Patent number: 8343730
    Abstract: A method is provided for determining in real time the course of proteolytic, e.g., thrombin activity, in a sample of clotting blood or plasma. By frequent mixing of a sample, clot formation may be controlled in a dense manner such that the majority of the sample remains fluid. This will inhibit cell precipitation and allow for informative monitoring as signal substrate is added.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: January 1, 2013
    Assignee: Thrombinoscope B.V.
    Inventors: Peter L. A. Giesen, Kerry Tappenden, Wynne Jones
  • Method for determining thrombin activity
    Patent number: 8133696
    Abstract: Methods and kits to determine thrombin activity are provided. They have the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a single-point measurement is adequate.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: March 13, 2012
    Assignee: Thrombinoscope B.V.
    Inventors: Peter L. A. Giesen, Timothy C. P. Van Asten