Abstract: The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also includes screening methods for identifying compounds that inhibit thrombin mediated activities.
Type:
Grant
Filed:
May 1, 2003
Date of Patent:
July 11, 2006
Assignees:
The Regents of the University of Michigan, Thromgen, Inc.
Abstract: The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is:
Arg-Gly-Lys-Z4-Cys
wherein:
Z4 is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is:
Arg-Gly-Asp-Z4-Cys
wherein:
Z4 is any naturally occurring amino acid, excluding cysteine.
Type:
Grant
Filed:
August 17, 1999
Date of Patent:
April 8, 2003
Assignees:
Thromgen, Inc., Regents of the University of Michigan