Abstract: A process for preparation of ?-ketoglutaric acid, L-arginine ?-ketoglutarate 1:1 and 2:1 includes the following steps. Provide a ?-ketoglutaratic acid aqueous solution at an adjusted concentration. Add one equivalent mole of solid L-arginine to the ?-ketoglutaratic acid aqueous solution. Stir and allow reaction under a controlled temperature. Obtain a resulting L-arginine ?-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine ?-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7. Obtain a final product of L-arginine ?-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine ?-ketoglutarate 1:1 and 97% for L-arginine ?-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.

Abstract: A process of preparation of ?-ketoglutaric acid for mass production of L-arginine ?-ketoglutarate 1:1 and 2:1 includes the steps of: reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain Dimethyl 2,2 -dichloroglutarate; reacting the dimethyl 2,2-dichloroglutarate with hydroxide solution to obtain crude ?-ketoglutaric acid aqueous solution; purifying the crude ?-ketoglutaric acid aqueous solution to obtain purified ?-ketoglutaric acid aqueous solution; and adjusting the concentration of the purified ?-ketoglutaric acid aqueous solution by adding water. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.