Abstract: Provided are polypeptides having the effects of inhibiting hepatitis B virus x protein (HBx) and polynucleotides encoding the peptides. Also provided are peptidomimetics, functional fragments and functional variants thereof, as well as the encoding genes thereof. The polypeptides and peptidomimetics can be used for the treatment and prevention of liver diseases resulted from hepatitis B virus infection, including hepatitis, cirrhosis and liver cancer.
Abstract: The present invention relates to the field of polypeptide medicine, and relates to polypeptides against hepatitis B virus X Protein and uses thereof. Specifically, the present invention relates to polypeptides comprising D-amino acids, which have a function of inhibiting hepatitis B virus X protein, and inhibit HBx activities, inhibit replication of hepatitis B virus DNA and expression of related antigens (e.g., HBeAg) at molecular level, cellular level and animal level, and further inhibit hepatitis and hepatic cirrhosis caused by hepatitis B virus infection and liver cancer that occurs on the basis of hepatic cirrhosis. The polypeptides can be widely used in the prevention and treatment of liver diseases after hepatitis B infection, including hepatitis, hepatic cirrhosis, and liver cancer.