Patents Assigned to TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGY
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Patent number: 12037316Abstract: The present disclosure discloses an energy-saving method for preparing electronic-grade carbonate, including the following steps that: industrial-grade dimethyl carbonate and anhydrous ethanol enter a reaction process after being preheated by a preheater, and are subjected to an esterification reaction under the action of a catalyst to obtain a mixture containing dimethyl carbonate, ethyl methyl carbonate and diethyl carbonate, and an azeotrope of dimethyl carbonate and methanol; the above-mentioned mixture enters a recovery process of dimethyl carbonate to recover unreacted dimethyl carbonate; a mixture of ethyl methyl carbonate and diethyl carbonate then enters a crude separation process to obtain crude ethyl methyl carbonate and crude diethyl carbonate; and the crude ethyl methyl carbonate is subjected to a refining process of ethyl methyl carbonate to obtain electronic-grade ethyl methyl carbonate, and the crude diethyl carbonate is subjected to a refining process of diethyl carbonate to obtain electronicType: GrantFiled: October 11, 2022Date of Patent: July 16, 2024Assignee: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Hongxing Wang, Haiyong Li, Guangqiang Zheng, Fei Li
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Publication number: 20240025756Abstract: The disclosure discloses a method for producing ?-calcium sulfate hemihydrate whiskers by using fermentation broth for producing lactic acid with a calcium salt method as a raw material and synchronously recovering a lactic acid monomer. The method comprises the following steps: 1) after fermentation of lactic acid is ended, heating fermentation broth; 2) stirring, and adding sulfuric acid for reaction; 3) after the reaction is ended, filtering and collecting a solid part, namely ?-calcium sulfite hemihydrate whiskers, and collecting a liquid part, namely a free lactic acid solution containing the lactic acid monomer; and 4) washing and drying the obtained ?-calcium sulfate hemihydrate whiskers to obtain a ?-calcium sulfate hemihydrate whisker finished product, filtering and concentrating the obtained free lactic acid solution to obtain a lactic acid crude product, and refining the lactic acid crude product to obtain a high-purity lactic acid monomer.Type: ApplicationFiled: February 3, 2021Publication date: January 25, 2024Applicant: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Zhengxiang WANG, Dandan NIU, Kangming TIAN, Fuping LU, Chunli SHEN
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Patent number: 11802300Abstract: A genetically engineered strain having high-yield of L-valine is disclosed. Starting from Escherichia coli W3110, an acetolactate synthase gene alsS of Bacillus subtilis is inserted into a genome thereof and overexpressed; a ppGpp 3?-pyrophosphate hydrolase mutant R290E/K292D gene spoTM of Escherichia coli is inserted into the genome and overexpressed; a lactate dehydrogenase gene ldhA, a pyruvate formate lyase I gene pflB, and genes frdA, frdB, frdC, frdD of four subunits of fumaric acid reductase are deleted from the genome; a leucine dehydrogenase gene bcd of Bacillus subtilis replaces a branched chain amino acid transaminase gene ilvE of Escherichia coli; and an acetohydroxy acid isomeroreductase mutant L67E/R68F/K75E gene ilvCM replaces the native acetohydroxy acid isomeroreductase gene ilvC of Escherichia coli. Furthermore, the L-valine fermentation method is improved by using a two-stage dissolved oxygen control. The L-valine titer and the sugar-acid conversion rate are increased.Type: GrantFiled: October 30, 2019Date of Patent: October 31, 2023Assignee: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Xixian Xie, Heyun Wu, Jiachu Wang, Faqing Wu, Xiaoqian Liu, Yanan Hao
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Publication number: 20230107828Abstract: A genetically engineered strain having high-yield of L-valine is disclosed. Starting from Escherichia coli W3110, an acetolactate synthase gene alsS of Bacillus subtilis is inserted into a genome thereof and overexpressed; a ppGpp 3?-pyrophosphate hydrolase mutant R290E/K292D gene spoTM of Escherichia coli is inserted into the genome and overexpressed; a lactate dehydrogenase gene ldhA, a pyruvate formate lyase I gene pflB, and genes frdA, frdB, frdC, frdD of four subunits of fumaric acid reductase are deleted from the genome; a leucine dehydrogenase gene bcd of Bacillus subtilis replaces a branched chain amino acid transaminase gene ilvE of Escherichia coli; and an acetohydroxy acid isomeroreductase mutant L67E/R68F/K75E gene ilvCM replaces the native acetohydroxy acid isomeroreductase gene ilvC of Escherichia coli. Furthermore, the L-valine fermentation method is improved by using a two-stage dissolved oxygen control. The L-valine titer and the sugar-acid conversion rate are increased.Type: ApplicationFiled: October 30, 2019Publication date: April 6, 2023Applicant: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Xixian XIE, Heyun WU, Jiachu WANG, Faqing WU, Xiaoqian LIU, Yanan HAO
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Patent number: 11413281Abstract: Disclosed is a targeted delivery system for a hydrophobic antitumor drug, referring to conjugates of E-selectin polypeptide ligand-polyethylene glycol-antitumor drug connected by different link bridges containing disulfide bonds. The synthesis of the conjugates, antitumor activity evaluation, the particle size and morphology characteristics of nanoparticles self-assembled by the conjugates in an aqueous solution, and the release of the antitumor drug in different conditions are comprised. The conjugates can actively target at vessels of a tumor site by the E-selectin peptide ligand, and can also self-assemble into nanoparticles in an aqueous solution, so as to be passively targeted at the tumor site by EPR effect.Type: GrantFiled: July 21, 2016Date of Patent: August 16, 2022Assignee: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGYInventors: Peng Yu, Na Guo, Dong Wang, Yuou Teng, Tiantian Hao, Huan Liu, Tianle Zhang, Xiuzhuan Shang
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Publication number: 20120255707Abstract: An inflatable wall material, including: a thermal insulation layer, a first metal layer, a barrier layer, a buffer layer, a protective layer, and a second metal layer. The first metal layer, the barrier layer, the buffer layer, the protective layer, and the second metal layer are arranged on two sides of the thermal insulation layer in sequence from the inside to the outside. The two barrier layers on the two sides of the thermal insulation layer employ air-tight materials. The two barrier layers and the first metal layers on the two sides of the thermal insulation layer constitute an inflatable air-tight space. The thermal insulation layer is positioned in the air-tight space.Type: ApplicationFiled: June 12, 2012Publication date: October 11, 2012Applicants: TIANJIN UNIVERSITY OF SCIENCE & TECHNOLOGY, Tianjin Hongmin Institute of Mini Cold Storage Room, Tianjin Gasin-DH Preservation Technologies Co., Ltd., Tianjin Lvxin Lower Temperature Technology & Science Co., Ltd.Inventors: Xihong LI, Yunbin JIANG, Yage XING, Shulai LU, Xiufeng LIU, Weili LI, Chongxiao SHAO, Haidong LIU