Patents Assigned to TIBA BIOTECH
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Publication number: 20240093238Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising sugar functionalized nucleic acid carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the delivery molecules are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.Type: ApplicationFiled: November 21, 2023Publication date: March 21, 2024Applicant: TIBA Biotech LLCInventors: Poulami Talukder, Jasdave Chahal
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Patent number: 11859201Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising sugar functionalized nucleic acid carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the delivery molecules are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.Type: GrantFiled: August 11, 2022Date of Patent: January 2, 2024Assignee: TIBA BIOTECH LLCInventors: Poulami Talukder, Jasdave Chahal
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Publication number: 20230346980Abstract: Tail-tail RNA conjugates translatable by eukaryotic ribosomes, and pharmaceutically acceptable compositions including the same are provided. Methods for preparing such molecules, using them for treating and preventing diseases are described. In addition, processes for producing desired polypeptides using the molecules are also described.Type: ApplicationFiled: April 27, 2023Publication date: November 2, 2023Applicant: Tiba BiotechInventors: Jasdave S CHAHAL, Justine S McPARTLAN
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Publication number: 20230310645Abstract: The present disclosure relates to nanoparticle compositions for delivery of nucleic acid agents. The nanoparticle composition disclosed includes a carrier containing a dendritic polymer skeleton, a PEG moiety, an amine, and a hydrophobic unit. The size of the PEG moiety may be limited, potentially reducing or avoiding anti-PEG antibody induction.Type: ApplicationFiled: April 3, 2023Publication date: October 5, 2023Applicant: Tiba Biotech LLCInventors: Poulami Talukder, Maria Varghese
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Publication number: 20230295241Abstract: Synthetic alphavirus-derived replicon expression systems comprising nucleic acid sequences encoding at least one modified nonstructural protein, and synthetic nucleic acid sequences encoding at least one heterologous protein are described. Methods of producing at least one heterologous protein in a cell, or of inducing an immune response in a subject by administering and/or expressing the synthetic alphavirus-derived replicon expression systems are provided.Type: ApplicationFiled: February 10, 2023Publication date: September 21, 2023Applicant: TIBA BIOTECHInventors: Jasdave S CHAHAL, Justine S. McPARTLAN
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Publication number: 20230149562Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising polyester (PE) dendrimers or dendrons, and therapeutic or immunogenic nucleic acid agents enclosed within the PE are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.Type: ApplicationFiled: April 2, 2021Publication date: May 18, 2023Applicant: TIBA Biotech LLCInventors: Poulami TALUKDER, Jasdave CHAHAL, Jin HUANG, Karl RUPING
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Publication number: 20230100837Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising sugar functionalized nucleic acid carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the delivery molecules are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.Type: ApplicationFiled: August 11, 2022Publication date: March 30, 2023Applicant: TIBA Biotech LLCInventors: Poulami Talukder, Jasdave Chahal
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Patent number: 11613561Abstract: Synthetic alphavirus-derived replicon expression systems comprising nucleic acid sequences encoding at least one modified nonstructural protein, and synthetic nucleic acid sequences encoding at least one heterologous protein are described. Methods of producing at least one heterologous protein in a cell, or of inducing an immune response in a subject by administering and/or expressing the synthetic alphavirus-derived replicon expression systems are provided.Type: GrantFiled: March 18, 2022Date of Patent: March 28, 2023Assignee: TIBA BIOTECH, LLCInventors: Jasdave S Chahal, Justine S McPartlan
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Publication number: 20220298210Abstract: Synthetic alphavirus-derived replicon expression systems comprising nucleic acid sequences encoding at least one modified nonstructural protein, and synthetic nucleic acid sequences encoding at least one heterologous protein are described. Methods of producing at least one heterologous protein in a cell, or of inducing an immune response in a subject by administering and/or expressing the synthetic alphavirus-derived replicon expression systems are provided.Type: ApplicationFiled: March 18, 2022Publication date: September 22, 2022Applicant: TIBA BIOTECHInventors: Jasdave S. CHAHAL, Justine S. McPARTLAN
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Publication number: 20210330600Abstract: Nanoparticle compositions for delivery of nucleic acids to subjects including modified dendrimers comprising cores, one or more of homogeneous or heterogeneous intermediate and terminal layers, and therapeutic or immunogenic nucleic acid agents enclosed within nanop article compositions are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.Type: ApplicationFiled: December 19, 2019Publication date: October 28, 2021Applicant: TIBA BIOTECH LLCInventors: Poulami TALUKDER, Jasdave CHAHAL, Justine McPARTLAN, Omar KHAN, Karl RUPING