Patents Assigned to Tidal Therapeutics, Inc.
  • NANOPARTICLE SYSTEMS TO STIMULATE AND MAINTAIN IMMUNE SYSTEM RESPONSIVENESS AT TREATMENT SITES
    Publication number: 20230331804
    Abstract: Nanoparticle systems that genetically modify monocytes/macrophages in vivo to (1) recruit additional immune cells to a treatment site; (2) remain activated at the treatment site providing an on-going stimulatory signal to other immune cells; and (3) secrete bispecific immune-cell engaging antibodies that bind antigens on cells of interest at the treatment site and also bind and activate the recruited immune cells to destroy the bound cell. The systems can also inhibit the activity of transforming growth factor beta (TGF?).
    Type: Application
    Filed: December 31, 2020
    Publication date: October 19, 2023
    Applicants: Fred Hutchinson Cancer Center, Tidal Therapeutics, Inc.
    Inventors: Matthias Stephan, Ulrik Nielsen
  • IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20220218614
    Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
    Type: Application
    Filed: December 3, 2021
    Publication date: July 14, 2022
    Applicant: Tidal Therapeutics, Inc.
    Inventors: Mir ALI, Austin Wayne BOESCH, Daryl Clark DRUMMOND, William KUHLMAN, Ulrik NIELSEN