Abstract: The present invention relates to an improved stem cell population for allogeneic stem cell therapy, in particular for the treatment of presensitized patients and for retreatment. Further, methods for obtaining said stem cell populations are provided. In addition, the present invention relates to pharmaceutical compositions comprising said stem cell populations and their use in allogeneic stem cell therapy.
Type:
Application
Filed:
February 26, 2020
Publication date:
June 30, 2022
Applicant:
TiGenix S.A.U.
Inventors:
Olga DE LA ROSA MORALES, Alvaro AVIVAR-VALDERAS
Abstract: The invention relates to methods for the cryopreservation of a stem cell population, including mesenchymal stem cells (MSCs) such as adipose-derived stromal stem cells (ASCs). More particularly, the invention relates to the use of N-acetylcysteine (NAC) in cryopreservation methods, populations of cells obtained from said methods, compositions comprising said cells and uses thereof.
Type:
Application
Filed:
February 11, 2020
Publication date:
April 7, 2022
Applicant:
TiGenix, S.A.U.
Inventors:
Eleuterio LOMBARDO DE LA CAMARA, Maitane ORTIZ VIRUMBRALES
Abstract: The invention relates to the use of mesenchymal stem cells (MSCs) for treating systemic inflammatory response syndrome (SIRS) in a subject. The invention provides compositions, uses and methods for the treatment of SIRS.
Type:
Application
Filed:
October 8, 2021
Publication date:
March 24, 2022
Applicants:
Consejo Superior de Investigaciones Cientificas, TiGenix, S.A.U., Universidad de Sevilla
Inventors:
Mario DELGADO, Elena GONZALEZ-REY, Dirk BÜSCHER
Abstract: A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and/or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.
Type:
Grant
Filed:
June 10, 2019
Date of Patent:
February 22, 2022
Assignees:
TIGENIX, S.A.U., Universidad Autonoma de Madrid
Inventors:
Damian Garcia-Olmo, Gema Fernandez Miguel, Manuel A. Gonzalez De La Pena, Mariano G. Arranz
Abstract: The invention relates to the use of mesenchymal stromal cells (MSCs) for treating sepsis in a subject. The invention provides compositions, uses and methods for the treatment of sepsis.
Type:
Application
Filed:
August 14, 2020
Publication date:
December 3, 2020
Applicant:
TiGenix, S.A.U.
Inventors:
Wilfried DALEMANS, Eleuterio LOMBARDO, Robert DEKKER
Abstract: The invention relates to a method for predicting the clinical response to a therapy based on the administration of mesenchymal stem cells (MSCs) in a patient suffering from an immune-mediated inflammatory disease. The invention also relates to methods of personalised medicine as well as to therapeutic uses of MSCs in a patient suffering from an immune-mediated inflammatory disease.
Abstract: Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising the cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.
Type:
Grant
Filed:
August 24, 2015
Date of Patent:
August 4, 2020
Assignees:
TIGENIX, S.A.U., UNIVERSIDAD AUTÓNOMA DE MADRID
Inventors:
Rosa Ana García Castro, María Gema Fernández Miguel, Mariano García Arranz, Manuel Angel González De La Peña, Damián García Olmo
Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
Type:
Grant
Filed:
March 17, 2014
Date of Patent:
May 26, 2020
Assignees:
TIGENIX NV, TIGENIX S.A.U.
Inventors:
Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans
Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.
Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.
Abstract: The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (IFN-?) by expressing indolamine-2,3-dioxygenase (IDO) for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to, autoimmune diseases, inflammatory disorders, and immunologically mediated diseases including rejection of transplanted organs and tissues.
Type:
Grant
Filed:
August 20, 2014
Date of Patent:
April 17, 2018
Assignees:
TIGENIX, S.A.U., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Inventors:
Dirk Büscher, Manuel Angel González De La Peña, Mario Delgado Mora
Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.