Patents Assigned to TiGenix, S.A.U.
  • Publication number: 20220202868
    Abstract: The present invention relates to an improved stem cell population for allogeneic stem cell therapy, in particular for the treatment of presensitized patients and for retreatment. Further, methods for obtaining said stem cell populations are provided. In addition, the present invention relates to pharmaceutical compositions comprising said stem cell populations and their use in allogeneic stem cell therapy.
    Type: Application
    Filed: February 26, 2020
    Publication date: June 30, 2022
    Applicant: TiGenix S.A.U.
    Inventors: Olga DE LA ROSA MORALES, Alvaro AVIVAR-VALDERAS
  • Publication number: 20220104481
    Abstract: The invention relates to methods for the cryopreservation of a stem cell population, including mesenchymal stem cells (MSCs) such as adipose-derived stromal stem cells (ASCs). More particularly, the invention relates to the use of N-acetylcysteine (NAC) in cryopreservation methods, populations of cells obtained from said methods, compositions comprising said cells and uses thereof.
    Type: Application
    Filed: February 11, 2020
    Publication date: April 7, 2022
    Applicant: TiGenix, S.A.U.
    Inventors: Eleuterio LOMBARDO DE LA CAMARA, Maitane ORTIZ VIRUMBRALES
  • Publication number: 20220088084
    Abstract: The invention relates to the use of mesenchymal stem cells (MSCs) for treating systemic inflammatory response syndrome (SIRS) in a subject. The invention provides compositions, uses and methods for the treatment of SIRS.
    Type: Application
    Filed: October 8, 2021
    Publication date: March 24, 2022
    Applicants: Consejo Superior de Investigaciones Cientificas, TiGenix, S.A.U., Universidad de Sevilla
    Inventors: Mario DELGADO, Elena GONZALEZ-REY, Dirk BÜSCHER
  • Patent number: 11253632
    Abstract: A biomaterial for suturing comprising a physiologically compatible support material coated with a cellular population with proliferative and/or differentiation capacity, characteristics which facilitate the regeneration of the sutured tissue. This biomaterial for suturing not only brings together the two edges of an open wound, but also contributes actively to the healing process, thereby accelerating the tissue repair process. Also disclosed are methods for making the biomaterial and methods for using the biomaterials in therapy.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: February 22, 2022
    Assignees: TIGENIX, S.A.U., Universidad Autonoma de Madrid
    Inventors: Damian Garcia-Olmo, Gema Fernandez Miguel, Manuel A. Gonzalez De La Pena, Mariano G. Arranz
  • Publication number: 20200376038
    Abstract: The invention relates to the use of mesenchymal stromal cells (MSCs) for treating sepsis in a subject. The invention provides compositions, uses and methods for the treatment of sepsis.
    Type: Application
    Filed: August 14, 2020
    Publication date: December 3, 2020
    Applicant: TiGenix, S.A.U.
    Inventors: Wilfried DALEMANS, Eleuterio LOMBARDO, Robert DEKKER
  • Patent number: 10780132
    Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: September 22, 2020
    Assignees: TiGenix, S.A.U., Universidad Autónoma de Madrid
    Inventors: María Gema Fernández Miguel, Manuel Ángel González De La Peña, Rosa Ana García Castro, Mariano García Arranz, Damián García Olmo
  • Patent number: 10758575
    Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: September 1, 2020
    Assignees: TiGenix, S.A.U., UNIVERSIDAD AUTÓNOMA DE MADRID
    Inventors: María Gema Fernández Miguel, Manuel Ángel González De La Peña, Rosa Ana García Castro, Mariano García Arranz, Damián García Olmo
  • Patent number: 10746729
    Abstract: The invention relates to a method for predicting the clinical response to a therapy based on the administration of mesenchymal stem cells (MSCs) in a patient suffering from an immune-mediated inflammatory disease. The invention also relates to methods of personalised medicine as well as to therapeutic uses of MSCs in a patient suffering from an immune-mediated inflammatory disease.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: August 18, 2020
    Assignee: TIGENIX, S.A.U.
    Inventors: Olga De La Rosa, Wilfried Dalemans
  • Patent number: 10729726
    Abstract: Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising the cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: August 4, 2020
    Assignees: TIGENIX, S.A.U., UNIVERSIDAD AUTÓNOMA DE MADRID
    Inventors: Rosa Ana García Castro, María Gema Fernández Miguel, Mariano García Arranz, Manuel Angel González De La Peña, Damián García Olmo
  • Publication number: 20200206274
    Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Application
    Filed: December 20, 2019
    Publication date: July 2, 2020
    Applicants: TiGenix, S.A.U., Universidad Autonoma de Madrid
    Inventors: María Gema FERNÁNDEZ MIGUEL, Manuel Angel GONZALEZ DE LA PENA, Rosa Ana GARCIA CASTRO, Mariano GARCIA ARRANZ, Damian GARCIA-OLMO
  • Patent number: 10660920
    Abstract: The present invention provides a method for determining the clinical prognosis of a human subject to the administration of a pharmaceutical composition comprising of stem cells (preferably mesenchymal stem cells), stromal cells, regulatory T-cells, fibroblasts and combinations thereof.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: May 26, 2020
    Assignees: TIGENIX NV, TIGENIX S.A.U.
    Inventors: Olga De La Rosa, Eleuterio Lombardo, Wilfried Dalemans
  • Patent number: 10548924
    Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: February 4, 2020
    Assignees: TIGENIX, S.A.U., UNIVERSIDAD AUTONOMA DE MADRID
    Inventors: Maria Gema Fernandez Miguel, Manuel Angel Gonzalez De La Pena, Rosa Ana Garcia Castro, Mariano Garcia Arranz, Damian Garcia-Olmo
  • Publication number: 20190381106
    Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.
    Type: Application
    Filed: June 25, 2019
    Publication date: December 19, 2019
    Applicant: TiGenix, S.A.U.
    Inventors: Eduardo BRAVO, Maria PASCUAL
  • Publication number: 20190269737
    Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Application
    Filed: February 1, 2019
    Publication date: September 5, 2019
    Applicants: TiGenix, S.A.U., Universidad Autónoma de Madrid
    Inventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
  • Patent number: 10357518
    Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: July 23, 2019
    Assignee: TIGENIX S.A.U.
    Inventors: Eduardo Bravo, Maria Pascual
  • Patent number: 9943550
    Abstract: The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (IFN-?) by expressing indolamine-2,3-dioxygenase (IDO) for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to, autoimmune diseases, inflammatory disorders, and immunologically mediated diseases including rejection of transplanted organs and tissues.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: April 17, 2018
    Assignees: TIGENIX, S.A.U., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Dirk Büscher, Manuel Angel González De La Peña, Mario Delgado Mora
  • Publication number: 20170258851
    Abstract: Provided herein are expanded allogeneic adipose tissue-derived stromal stem cells for use in treating complex perianal fistulas in Crohn's Disease.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 14, 2017
    Applicant: TIGENIX S.A.U.
    Inventors: Eduardo BRAVO, Maria PASCUAL
  • Publication number: 20170209496
    Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 27, 2017
    Applicants: TiGenix, S.A.U., Universidad Autónoma de Madrid
    Inventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
  • Publication number: 20170189452
    Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.
    Type: Application
    Filed: March 23, 2017
    Publication date: July 6, 2017
    Applicants: TiGenix, S.A.U., Universidad Autónoma de Madrid
    Inventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO
  • Publication number: 20170189451
    Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stern cells for treating fistulae.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Applicants: TiGenix, S.A.U., Universidad Autónoma de Madrid
    Inventors: María Gema FERNÁNDEZ MIGUEL, Manuel Ángel GONZÁLEZ DE LA PEÑA, Rosa Ana GARCÍA CASTRO, Mariano GARCÍA ARRANZ, Damián GARCÍA OLMO