Patents Assigned to TIGO GMBH
  • Suppressor of the endogenous interferon-gamma
    Patent number: 9359421
    Abstract: The invention relates to suppressors of endogenous human interferon-gamma (INF-?) applicable in treatment of diseases associated with impaired activity of endogenous IFN-?. The suppressors of the invention are useful in treating autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. The invention includes inactive analogues or variants of IFN-? having preserved affinity to the IFN-? receptor, genetically modified in the domain responsible for triggering the signal transduction pathway.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: June 7, 2016
    Assignee: TIGO GmbH
    Inventors: Ivan Ivanov, Genoveva Nacheva, Stefan Petrov, Hans-Guenther Grigoleit
  • SUPPRESSOR OF THE ENDOGENOUS INTERFERON-GAMMA
    Publication number: 20140212383
    Abstract: The invention relates to suppressors of endogenous human interferon-gamma (INF-?) applicable in treatment of diseases associated with impaired activity of endogenous IFN-?. The suppressors of the invention are useful in treating autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. The invention includes inactive analogues or variants of IFN-? having preserved affinity to the IFN-? receptor, genetically modified in the domain responsible for triggering the signal transduction pathway.
    Type: Application
    Filed: April 2, 2014
    Publication date: July 31, 2014
    Applicant: TIGO GMBH
    Inventors: Ivan Ivanov, Genoveva Nacheva, Stefan Petrov, Hans-Guenther Grigoleit