Abstract: The present invention relates to a drug-impregnated implantable medical device such as stent manufactured from polymers, and more particularly, biodegradable polymers including biodegradable polyesters. The invented medical devices include at least one therapeutic agent impregnated in at least one biodegradable polymer wherein at least a portion of the therapeutic agent in this polymer is crystalline. The device and methods to impregnated one or more therapeutic agents, where each therapeutics agent may be chosen from the following categories: immunosuppressant agents, anti-neoplastic agents and anti-inflammatory agents were disclosed. Other embodiments include methods of fabricating drug-impregnated implantable medical devices.