Abstract: A latching mechanism (26) for an adjustable squeeze-off clamp (10) comprising a static jaw (16), a movable jaw (18) with an associated adjustment member (20) and an over-the-center operating linkage including an operating handle (23) and a link (24). The latching mechanism is selectively automatic whereby, when the lock mode is selected and the clamp is then closed, it automatically locks. The latch mechanism includes a spring (32) and a latch bar (28) with pivotal mounting (30) and notched end (36). In at least one embodiment, the latching mechanism includes an eccentric knob (42) for selection of the automatic locking mode.