Abstract: An applicator (1) comprising: a body (2) defining a chamber (14) for storing an adhesive composition, and an outlet (16) for delivering the adhesive composition stored in the chamber (14), a piston (4) mobile in translation relative to the body (2), a drive element (6) mobile in rotation relative to the body (2), and configured to be releasably engaged with a guide (100, 200, 300) external to the applicator (1), wherein rotating the drive element (6) relative to the body (2) causes the piston (4) to translate relative to the body (2) so as to reduce a volume of the chamber (14) and force the adhesive composition out of the applicator (1) through the outlet (16).

Abstract: A composition with improved adhesive and sealant properties comprising a pre-polymer comprising a polymeric unit of the general formula (1A1B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, wherein the compositions has a grafted anhydride content of less than about 0.05 mol/mol of polyacid.

Abstract: A device for applying adhesive composition to biological tissue and/or prosthetic material includes a flexible body, wherein the body has an upper surface that includes a first shoulder defining a first recess. The body is adapted to be folded on itself in a folded position in which the body defines a channel and in which the first recess forms an annular gap between the upper surface and the biological tissue and/or prosthetic material when the biological tissue and/or prosthetic material is positioned in the channel.

Abstract: A composition with improved adhesive and sealant properties comprising a) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, and b) an anhydride compound.

Abstract: Applicator for depositing a layer of adhesive or sealant composition on a target site of a biological and/or prosthetic tissue, the applicator including a body having an application face intended to be positioned facing the biological and/or prosthetic tissue, and having a first outlet opening provided in the application face, the first outlet opening being shaped as a slot for allowing the adhesive or sealant composition to flow out of the applicator and to form the layer of adhesive or sealant composition, a second inlet opening provided in the application face, adjacent the first outlet opening, for allowing pollutants or undesirable elements to be removed from the target site while depositing the layer of adhesive or sealant composition, wherein the first outlet opening has a first section and the second inlet opening has a second section, the second section being greater than the first section.

Abstract: A 3D printing resin composition for a biomaterial and method for 3D printing the composition are disclosed. The composition comprises: (i) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1, (ii) at least one photo-initiator, and (iii) at least one light blocker.