Patents Assigned to Tissue Genesis, LLC
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Publication number: 20190112570Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.Type: ApplicationFiled: December 13, 2018Publication date: April 18, 2019Applicant: TISSUE GENESIS, LLCInventors: Rolf WOLTERS, Jules VALENTI, Tom GURSKI
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Publication number: 20180002666Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.Type: ApplicationFiled: September 18, 2017Publication date: January 4, 2018Applicant: Tissue Genesis, LLCInventors: Rolf WOLTERS, Anthony YANG, Josh NELSON, Stuart K. WILLIAMS
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Patent number: 9683210Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.Type: GrantFiled: September 28, 2015Date of Patent: June 20, 2017Assignee: Tissue Genesis, LLCInventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams
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Publication number: 20160237396Abstract: The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.Type: ApplicationFiled: September 28, 2015Publication date: August 18, 2016Applicant: Tissue Genesis, LLCInventors: Gregory D. Ariff, Thomas Cannon, Jennifer L. Case, Christian L. Haller, Paul Kosnik, Charles P. Luddy, Craig A. Mauch, Erik Vossman, Stuart K. Williams