Abstract: Provided is a microsphere comprising a bead coated with a first calcium-containing mineral. Also provided is a method of producing a microsphere. Additionally, a method of administering a compound to a vertebrate is provided.
Type:
Application
Filed:
September 25, 2009
Publication date:
June 12, 2014
Applicant:
TISSUE REGENERATION SYSTEMS, INC.
Inventors:
William L. Murphy, Leenaporn Jongpaiboonkit
Abstract: Provided are biocompatible and implantable scaffolds for treating a tissue defect, such as a bone gap. The scaffolds can have a modular design comprising a tissue scaffold rack designed to accommodate one or more modules. Also provided are methods for fabrication and use of such scaffolds.
Type:
Application
Filed:
February 28, 2012
Publication date:
October 25, 2012
Applicant:
TISSUE REGENERATION SYSTEMS, INC.
Inventors:
Scott J. Hollister, Stephen E. Feinberg, William L. Murphy, Leenaporn Jongpaiboonkit, James R. Adox, Francesco Migneco
Abstract: A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and/or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.
Type:
Application
Filed:
February 28, 2011
Publication date:
November 17, 2011
Applicant:
TISSUE REGENERATION SYSTEMS, INC.
Inventors:
William L. Murphy, Chia-Ying Lin, Frank LaMarca, Scott J. Hollister