Patents Assigned to Tissue Systems Holding GmbH
  • Multiloop engineered heart muscle tissue
    Patent number: 10894946
    Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived from human cells and their use in drug screening and target validation assays.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: January 19, 2021
    Assignee: Tissue Systems Holding GmbH
    Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen
  • Multiloop engineered heart muscle tissue
    Patent number: 10494605
    Abstract: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and a device for preparing the same. Finally, the invention relates to force-generating engineered heart tissue rings derived human cells and their use in drug screening and target validation assays.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: December 3, 2019
    Assignee: Tissue Systems Holding GmbH
    Inventors: Wolfram-Hubertus Zimmermann, Thomas Eschenhagen