Patents Assigned to TissueGen, Inc.
  • Methods and compositions for maintaining the conformation and structural integrity of biomolecules
    Patent number: 12121560
    Abstract: A liquid ink composition includes a liquid phase and particles suspended in the liquid phase, the particles containing a target pharmaceutical or biological agent. The biological activity of the target pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase. The liquid phase is capable of solidifying via a solidification process.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: October 22, 2024
    Assignee: TissueGen, Inc.
    Inventors: Paul R. Sood, Alpeshkumar P. Patel, Jennifer Seifert, Ryszard Zarzycki
  • Methods and compositions for maintaining the conformation and structural integrity of biomolecules
    Patent number: 11197905
    Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: December 14, 2021
    Assignee: TissueGen, Inc.
    Inventors: Jennifer Seifert, Paul R. Sood, Brent B. Crow, Kevin D. Nelson, Nickolas B. Griffin, Alpeshkumar P. Patel, Paul A. Hubbard
  • Drug-eluting self-retaining sutures and methods relating thereto
    Patent number: 11007296
    Abstract: A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: May 18, 2021
    Assignees: Ethicon, Inc., Ethicon, LLC, Tissuegen, Inc.
    Inventors: Jeffrey M. Gross, Lev Drubetsky, Alexander Naimagon, Rui Avelar, William L. D'Agostino, Kevin Don Nelson, Brent B. Crow, Nickolas B. Griffin
  • Methods and compositions for maintaining the conformation and structural integrity of biomolecules
    Patent number: 10363281
    Abstract: A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: July 30, 2019
    Assignee: TissueGen, Inc.
    Inventors: Kevin D. Nelson, Brent B. Crow, Nickolas B. Griffin, Jennifer Seifert, Paul R. Sood, Alpeshkumar P. Patel, Paul A. Hubbard
  • Self-expanding medical device
    Patent number: 8672996
    Abstract: The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: March 18, 2014
    Assignee: TissueGen, Inc.
    Inventors: Kevin D. Nelson, Paula J. Taylor, Brent B. Crow
  • SELF-EXPANDING MEDICAL DEVICE
    Publication number: 20110172755
    Abstract: The invention relates to a helical coil comprising multiple reversing sense helical coil units that are capable of drug elution, come in lengths appropriate for long, diffuse lesions, have the ability to have a step-wise tapering diameter, and provide all the benefits of a small closed cell stent design while maintaining high flexibility, high radial force and crush resistance due to an underlying helical coil.
    Type: Application
    Filed: August 19, 2009
    Publication date: July 14, 2011
    Applicant: TissueGen, Inc.
    Inventors: Kevin D. Nelson, Paula J. Taylor, Brent B. Crow