Patents Assigned to TissueTech, Inc.
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Publication number: 20160243288Abstract: The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.Type: ApplicationFiled: February 23, 2016Publication date: August 25, 2016Applicant: TissueTech, Inc.Inventors: Scheffer TSENG, Ek Kia TAN
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Patent number: 9198939Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: March 13, 2013Date of Patent: December 1, 2015Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 9175066Abstract: Disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of I?I, wherein the transfer of the heavy chain of I?I is catalyzed by TSG-6. Further disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of I?I, wherein the transfer of the heavy chain of I?I is catalyzed by the TSG-6 like protein. Additionally, disclosed herein are methods of manufacturing said complex and methods of use thereof.Type: GrantFiled: April 26, 2010Date of Patent: November 3, 2015Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He
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Patent number: 9161956Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: March 13, 2013Date of Patent: October 20, 2015Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 9161955Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: March 13, 2013Date of Patent: October 20, 2015Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He, Wei Li
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Patent number: 9161954Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: GrantFiled: March 12, 2013Date of Patent: October 20, 2015Assignee: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He, Wei Li
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Publication number: 20150203814Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.Type: ApplicationFiled: December 22, 2014Publication date: July 23, 2015Applicant: TISSUETECH, INC.Inventors: Scheffer TSENG, Szu-Yu CHEN, Suzhen ZHANG
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Publication number: 20150166624Abstract: Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (I?I). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.Type: ApplicationFiled: July 10, 2013Publication date: June 18, 2015Applicant: TISSUETECH, INC.Inventors: Scheffer Tseng, Hua He, Sean Tighe, Suzhen Zhang, Ying-Tieng Zhu
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Patent number: 9006192Abstract: Described herein are methods and compositions for stimulating proliferation of cells that express adherent junctions and cease proliferation, for example, human corneal endothelial cells, by downregulation of certain cell-cell junctions. In one embodiment, downregulation is achieved using RNA interference, and contacting the cells with mitogenic growth factors and an agent that elevates intracytoplasmic cAMP. Furthermore, described herein are methods of isolating human corneal endothelial cells from keratocytes, and methods of preserving and maintaining viability of human corneal endothelial cell aggregates. Also described are surgical grafts comprising human corneal endothelial cells that have been isolated, optionally stored, and transiently contacted with an agent that downregulates expression of p 120, and a biocompatible support.Type: GrantFiled: September 27, 2007Date of Patent: April 14, 2015Assignee: TissueTech, Inc.Inventors: Scheffer Tseng, Wei Li, Yingting Zhu
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Patent number: 8940294Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.Type: GrantFiled: March 1, 2013Date of Patent: January 27, 2015Assignee: Tissuetech, Inc.Inventors: Scheffer Tseng, Szu-Yu Chen, Suzhen Zhang
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Publication number: 20140342014Abstract: Disclosed herein, are methods of preparing sterilized amniotic tissues. Further disclosed herein, are methods of using the sterilized amniotic tissues.Type: ApplicationFiled: August 24, 2012Publication date: November 20, 2014Applicant: TISSUETECH, INC.Inventors: Scheffer Tseng, Ek Kia Tan
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Patent number: 8865233Abstract: Compositions containing about 0.6% to about 20% of tea tree oil are described. Some compositions are in the form of solutions, suspensions, spray, lotions, gels, pastes, medicated sticks, balms, cleansers (including shampoos and soaps), creams, or ointments. Also described are compositions and methods for use in treating ocular Demodex infestations and related conditions using such compositions.Type: GrantFiled: April 8, 2013Date of Patent: October 21, 2014Assignee: Tissuetech, Inc.Inventors: Ying-Ying Gao, Scheffer Tseng
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Patent number: 8865232Abstract: The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.Type: GrantFiled: April 4, 2013Date of Patent: October 21, 2014Assignee: TissueTech, Inc.Inventors: Ying-Ying Gao, Scheffer Tseng
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Publication number: 20140112998Abstract: Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.Type: ApplicationFiled: April 27, 2012Publication date: April 24, 2014Applicant: TISSUETECH, INC.Inventors: Scheffer Tseng, Ek Kia Tan, Hua He
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Publication number: 20140106448Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent cells (e.g., MSCs and ASCs) using a first culture in a suitable 2-dimensional substrate and a second culture in a suitable 3-dimensional substrate containing the basement membrane component and ROCK inhibitors. Also described are multipotent cell cultures made by the methods. Multipotent cell cultures as described may be used for transplantation or as niche cells for supporting other types of stem cells.Type: ApplicationFiled: April 30, 2012Publication date: April 17, 2014Applicant: TissueTech, Inc.Inventors: Szu-yu Chen, Scheffer Tseng
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Publication number: 20130344128Abstract: The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.Type: ApplicationFiled: April 4, 2013Publication date: December 26, 2013Applicant: TissueTech, Inc.Inventor: TissueTech, Inc.
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Publication number: 20130280344Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: ApplicationFiled: March 13, 2013Publication date: October 24, 2013Applicant: TISSUETECH, INC.Inventor: TissueTech, Inc.
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Publication number: 20130251684Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.Type: ApplicationFiled: March 1, 2013Publication date: September 26, 2013Applicant: TISSUETECH, INC.Inventors: Scheffer Tseng, Szu-Yu Chen, Suzhen Zhang
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Publication number: 20130224272Abstract: Compositions containing about 0.6% to about 20% of tea tree oil are described. Some compositions are in the form of solutions, suspensions, spray, lotions, gels, pastes, medicated sticks, balms, cleansers (including shampoos and soaps), creams, or ointments. Also described are compositions and methods for use in treating ocular Demodex infestations and related conditions using such compositions.Type: ApplicationFiled: April 8, 2013Publication date: August 29, 2013Applicant: TissueTech, Inc.Inventor: TissueTech, Inc.
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Publication number: 20130195992Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.Type: ApplicationFiled: March 12, 2013Publication date: August 1, 2013Applicant: TISSUETECH, INC.Inventor: TissueTech, Inc.