Abstract: Apparatus for filling sterile containers is disclosed which defines an elongated but narrow sterile zone in which a number of operating stations are disposed. An elongated vertical wall is carried by an elongated frame and a cabinet type enclosure cooperates with the vertical wall to define the sterile zone. The plurality of operating stations are disposed in sequential relation over the length of the sterile zone, and an elongated container conveyor is disposed within the sterile zone to convey the containers through the plurality of operating stations. The conveyor is vertically oriented, consisting an endless belt mounted on end wheels that rotate on horizontal axes. Each of the operating stations includes an operating portion disposed within the sterile zone. Actuating means are included for each of the operating stations as well as the elongated conveyor, each of which is disposed outside the sterile zone.

Abstract: A microbial barrier isolation system for enclosing and decontaminating equipment so that the equipment may be used in handling or otherwise contacting biologically-sensitive materials such as parenteral solutions and solids. The barrier system is formed with a lower cavity, an upper chamber separated from the inner cavity by filters, an air return conduit, means for supplying dry, heated air to heat the system and means for using steam and hydrogen peroxide to decontaminate the internal parts of the system. The decontamination process involves using dry air to heat the internal equipment of the system to reduce water condensation and then introducing saturated steam and peroxide at a positive pressure slightly above atmospheric pressure. The internal equipment, including all surfaces, is exposed to the steam and peroxide sterilant for a sufficient time to decontaminate the equipment and the system is cooled down with cool, sterile air.

Abstract: Apparatus is disclosed for dispensing materials into containers in precise amounts, which includes an adjustment mechanism for precisely controlling the volume of material dispensed. The dispensing apparatus comprises a dispensing wheel having a plurality of dispensing chambers arranged in a radial manner on the wheel. Each chamber includes a mechanism for varying its volume and hence the quantity of the substance received and discharged. The adjustment mechanism includes an externally accessible toothed wheel which is rotatable in one direction to increase the volume of the chamber and is rotatable in the opposite direction to decrease the chamber volume. First and second actuators are disposed relative to the dispensing wheel and are selectively operated to engage the toothed wheel on opposite sides of its rotational axis.

Abstract: A pharmaceutical filler apparatus (20) is disclosed. The pharmaceutical filler apparatus (20) cooperates with a conveyor (22) conveying containers to position each of the containers proximate a fluid delivery conduit (36) for receipt of fluid. The present invention further includes a reservoir (42) positioned above the containers at a predetermined height, the fluid being maintained in the reservoir at a constant level. The pharmaceutical apparatus (20) further includes a quick acting pinch valve (50) associated with the fluid delivery (36) for opening and closing the fluid delivery conduit (36). The pinch valve apparatus (50) includes a biasing spring (98) for biasing a valve apparatus (50) into a first position whereby the fluid delivery conduit (36) is closed. A cam actuator apparatus (54) cooperates with the pinch valve apparatus (50) to position the pinch valve (50) in a second position whereby the fluid delivery conduit (36) is opened.

Abstract: A manipulator apparatus (10) for performing a plurality of motions is disclosed. The apparatus (10) includes a rotatable support shaft (14) supported on a frame (12) for rotary motion. A plurality of discrete cams (16-22) are supported in a spaced relationship on the support shaft. An individual coupling mechanism (26-32) couples each of the cams to a motion transmitting device. Each coupling mechanism (26-32) includes a cam follower (146, 280, 333). Individual force limiting mechanisms (158, 404) are provided for each of the coupling mechanisms (26-32) for uncoupling a respective coupling mechanism when a force beyond a predetermined level is reached in the respective coupling mechanism.