Abstract: There is disclosed a multi-layer tape system for applying register marks or other symbols to aligned artwork sheets used in the graphic arts field. In a two-layer system each of two superimposed clear tapes has aligned markings printed thereon. A weak adhesive secures the two tapes together, and the two outer surfaces are coated with a strong adhesive. In a four-layer system, a separator is disposed between a pair of two-layer systems; the separator has holes therein so that the two tape systems can adhere to each other and remain in alignment, contact being made in the regions of the holes. The relative adhesive strengths maintain the system integrity prior to use while also permitting tape separation during use.