Abstract: The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia-related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncated Disc1 genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc1 polypeptide truncated before exon 9; (2) 2 copies of endogenous Disc1 genomic DNA sequence encoding full length Disc1 polypeptide. Also provided are related materials and methods.
Type:
Application
Filed:
July 16, 2009
Publication date:
November 29, 2012
Applicants:
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, WYETH PHARMACEUTICALS INC., TMRI LIMITED
Inventors:
Sanbing Shen, Gernot Riedel, David St. Clair