Patents Assigned to Tod Mitchell Woolf
  • Three component chimeric antisense oligonucleotides
    Patent number: 5989912
    Abstract: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: November 23, 1999
    Assignees: Oligos Etc. Inc., Tod Mitchell Woolf
    Inventors: Amy Arrow, Roderic M. K. Dale, Tod Mitchell Woolf
  • Three component chimeric antisense oligonucleotides
    Patent number: 5849902
    Abstract: This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: a RNase H activating region, a complementarity region and 3' and 5' ends. The invention optimizes each of the components to resist intracellular nucleases, to increase hybridization to target mRNA, to specifically inactivate target mRNA in cells, and to decrease cytotoxicity.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: December 15, 1998
    Assignees: Oligos Etc. Inc., Tod Mitchell Woolf
    Inventors: Amy Arrow, Roderic M.K. Dale, Tod Mitchell Woolf