Abstract: Disclosed is an autofluorescence quenching device that: quenches only autofluorescence without quenching fluorescence that is originally desired to be observed in a tissue section in a short time; does not emit noise in various wavelength regions; is capable of controlling a temperature increase; can be used repeatedly with a simple operation; and can stably quenches autofluorescence. The autofluorescence quenching device for a sample includes: a sample placement unit; and an irradiation unit mounted on the sample placement unit. The sample placement unit includes: a flat plate; one or more sample placement recesses each in which a sample is to be placed and which are provided in the flat plate; and a cooling means for cooling the sample placement recesses. The irradiation unit includes one or a plurality of white LED illuminations placed above the respective sample placement recesses.

Abstract: The present invention provides a primer set for detecting the presence of Staphylococcus argenteus in a specimen, the primer set comprising: a first primer; and a second primer, in which the first primer and the second primer target a nuc gene of Staphylococcus argenteus.

Abstract: The present invention provides a primer set for detecting the presence of Klebsiella variicola in a specimen, wherein the primer set consists of a first primer and a second primer that target the gyrB gene of Klebsiella variicola.

Abstract: This invention provides a simple analysis method by a PCR method that simultaneously performs, in a single container, separating nucleic acid of pathogens contained in a tissue fragment and preparing a PCR buffer solution, and a kit used for the analysis method. A method for detecting a pathogen includes: (1) obtaining a liquid specimen mixture by adding a tissue fragment containing a pathogen to a PCR buffer solution containing a proteolytic enzyme; (2) heating the liquid specimen mixture at a first temperature; (3) further heating at a second temperature; (4) performing PCR by adding a portion of the liquid mixture obtained in (3) above to a solid composition for PCR reaction containing DNA polymerase and one or more kinds of PCR primer pair; and (5) detecting a PCR product generated in (4) above.

Abstract: A method for allowing an animal to develop atrioventricular block, the method including: administering an immune regulator targeting a sphingosine-1-phosphate receptor to an animal selected from a pig, a monkey and a guinea pig.

Abstract: A template 13 comprises a cusp base forming part 11 having a shape corresponding to a cusp base is provided to obtain cusp material for dispersing stresses exerted on the cusp. Such a cusp forming template may further comprise wing forming parts 15 corresponding to wing parts provided outside the cusp base forming part 11. As examples of the wing forming part, there may be employed a single or plural holes provided at a part or parts corresponding to the outline of each wing, and guide parts provided at parts corresponding to the outline of wings.

Abstract: A cardiac massage practice device including a simulated heart, a simulated vein, a simulated artery, and a mannequin of an upper half of a human body, wherein the simulated heart contracts from a stationary state to be deformable to a contracted state, and dilates from the stationary state to be deformable to a dilated state, wherein the simulated vein is coupled to the simulated heart, and when the simulated heart dilates from the contracted state, transfers virtual blood to an inside of the simulated heart, wherein the simulated artery is coupled to the simulated heart, and when the simulated heart contracts from the dilated state, transfers the virtual blood transferred to the inside of the simulated heart from the inside of the simulated heart to an outside of the simulated heart, and wherein the mannequin of the upper half of the human body houses the simulated heart therein.

Abstract: An objective of the present invention is to provide a caged compound that can be photoactivated selectively for specific target cell types and can be used in an individual organism. The objective can be achieved by a compound represented by general formula K-Q-X, which is prepared by binding bioactive substance X, photocleavable protecting group Q, and compound K, which can be an enzyme substrate and is dissociated from Q-X by an enzyme reaction, wherein: Q is a protecting group that is photocleaved by light with a specific wavelength and then dissociated from X, when K is not bound thereto; X is a substance that does not express bioactivity when Q is bound thereto, but expresses bioactivity when Q is dissociated therefrom; and K is dissociated from Q by the above enzyme, so as to form a compound represented by Q-X.

Abstract: An object of the present invention is to enable simpler operation in real time and culture while removing unnecessary cells from cultured cells for purification in analyzing, fractionating, and culturing the cells alive and to analyze and fractionate desired cells from the cultured cells to increase the purity, recovery rate, and viability of the cells. The present invention employs a cell-adhesive photocontrollable base material, wherein light irradiation causes the bond dissociation of a photolabile group comprising a coumarinylmethyl skeleton to produce the separation of a cell-adhesive material to leave a non-cell-adhesive material. As a result, cell images can be detected and analyzed to obtain the positional information of desired cells. Based on the positional information thus obtained, the cells can be analyzed and fractionated alive.

Abstract: A method for allowing an animal to develop atrioventricular block, the method including: administering an immune regulator targeting a sphingosine-1-phosphate receptor to an animal selected from a pig, a monkey and a guinea pig.

Abstract: A method for preventing or treating atrial fibrillation, including: administering, to an individual, an atrial fibrillation inhibitor containing a compound expressed by one of the following Structural Formulas (I) to (VI) or a pharmacologically acceptable salt thereof: where in the Structural Formula (III), Gluc refers to glucuronic acid,

Abstract: It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine. The present invention relates to a pharmaceutical or food composition for ?2 receptor blockage comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (wherein R1 represents a hydrogen, alkyl group, alkenyl group, alkynyl group, aromatic group, aralkyl group, acyl group, arylsulfonyl group, alkylsulfonyl group, or hydroxyl group; R2 represents a hydrocarbon group; R3, R4, R5, R6, and R7 are the same or different and represent a hydrogen, halogen, alkyl group, or alkoxy group; R8 represents a hydrogen or acyl group; n represents an integer of 1 to 6; and a and b are the same or different and represent 1 or 0).