Patents Assigned to Tokiwa, Phytochemical Co., Ltd.
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Publication number: 20230241144Abstract: Pharmaceutical preparations, Chinese herbal preparations, foods, and other compositions may contain, as an active ingredient, an ephedra extract, an ephedrine-alkaloid-free ephedra extract, or a polymercondensed tannin derived from an ephedra extract. Such compositions may be useful for preventing or treating COVID-19 infection (COVID-19). Such compositions are preferably provided in an orally ingestible form.Type: ApplicationFiled: October 1, 2021Publication date: August 3, 2023Applicants: THE KITASATO INSTITUTE, JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES, Matsuyama University, TOKIWA PHYTOCHEMICAL CO., LTD., TSUMURA & CO.Inventors: Toshihiko HANAWA, Sumiko HYUGA, Hiroshi ODAGUCHI, Yukihiro GODA, Masashi HYUGA, Masashi UEMA, Hiroshi ASAKURA, Nahoko UCHIYAMA, Yoshiaki AMAKURA, Morio YOSHIMURA, Jinwei YANG, Kazushige MIZOGUCHI
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Patent number: 11452756Abstract: The present invention relates to a composition and method for improving the quantity of tear fluid, a composition and method for treating constipation, and a composition and method for improving skin quality. By utilizing an extract of Black ginger (Kaempferia parviflora)), the quantity of tear fluid, constipation, and skin quality are improved.Type: GrantFiled: April 21, 2020Date of Patent: September 27, 2022Assignee: TOKIWA PHYTOCHEMICAL CO., LTD.Inventors: Jinwei Yang, Tomoko Kuniyoshi
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Patent number: 11154581Abstract: A composition and method for the prevention and/or improvement of dry eye syndrome, dryness of eye and/or stiff neck and shoulder, which contains bilberry fruit extract and is effective with less intake are provided. As one aspect of the present invention, the composition for the prevention or improvement of dry eye syndrome or dryness of eye contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, the composition for the prevention or improvement of stiff neck and shoulder contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a composition for the prevention or improvement of dry eye syndrome, dryness of eye, and stiff neck and shoulder, contains a freeze-dried bilberry fruit extract. As another aspect of the present invention, a method using a bilberry fruit extract for the improvement of stiff neck and shoulder is provided.Type: GrantFiled: January 13, 2020Date of Patent: October 26, 2021Assignee: TOKIWA PHYTOCHEMICAL CO., LTD.Inventor: Jinwei Yang
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Patent number: 10889557Abstract: A method of producing an alkoxyflavone derivative involves a step of reacting hydroxyflavone derivative which is shown in the below chemical formula and dialkyl sulfate in the presence of dimethyl sulfoxide and an alkali hydroxide. Further, in the chemical formula below, R11-R14, R21-R25 and R3 are independently one of hydrogen, hydroxyl group, ester group, alkoxy group, alkylenedioxy group, sulfonyl group and alkyl group, respectively. However, at least two of R21-R25 and R3 are hydroxyl groups.Type: GrantFiled: December 26, 2019Date of Patent: January 12, 2021Assignee: TOKIWA PHYTOCHEMICAL CO., LTD.Inventors: Jin Tatsuzaki, Tsutomu Ishikawa
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Patent number: 10377902Abstract: A crystalized red pigment of saw palmetto fruit obtained by extracting a saw palmetto fruit with ethanol and depositing a red pigment in the extract.Type: GrantFiled: October 4, 2013Date of Patent: August 13, 2019Assignees: HEIMAT CO., LTD., MASAO TAKAHASHI, TOKIWA PHYTOCHEMICAL CO., LTD.Inventors: Masao Takahashi, Nobuhito Kimura
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Patent number: 9745279Abstract: The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.Type: GrantFiled: December 27, 2012Date of Patent: August 29, 2017Assignees: TOKIWA PHYTOCHEMICAL CO., LTD.Inventors: Tsutomu Shimada, Jinwei Yang, Yuka Koike
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Publication number: 20160297971Abstract: A crystalized red pigment of saw palmetto fruit obtained by extracting a saw palmetto fruit with ethanol and depositing a red pigment in the extract.Type: ApplicationFiled: October 4, 2013Publication date: October 13, 2016Applicants: TOKIWA PHYTOCHEMICAL CO., LTD., HEIMAT CO., LTD.Inventors: Masao TAKAHASHI, Nobuhito KIMURA
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Publication number: 20140348961Abstract: The present invention provides a sirtuin activator with an active component composed of black ginger or a black ginger extract, which is easily obtainable, extremely safe, and eaten from old. The present invention further provides a sirtuin activator with an active component of polyalkoxyflavonoid compound represented by general formula (I) and having a sirtuin activation effect that is 10 folds that of resveratrol or higher: wherein, R1 to R7 are each independently a hydrogen atom, a hydroxyl group, or a C1 to C6 lower alkoxy group.Type: ApplicationFiled: December 27, 2012Publication date: November 27, 2014Applicants: TOKIWA PHYTOCHEMICAL CO., LTD.Inventors: Tsutomu Shimada, Jinwei Yang, Yuka Koike
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Patent number: 8101795Abstract: According to the present invention, there is provided a process for preparing corosolic acid comprising the steps of (1) dissolving crude extract of Japanese loquat leaves in alkali and aqueous alcohol and (2) applying the solution to a nonpolar adsorption resin to obtain corosolic acid.Type: GrantFiled: December 27, 2007Date of Patent: January 24, 2012Assignees: Kenko Corporation, Tokiwa Phytochemical Co., Ltd.Inventors: Naoaki Yoshida, Chihiro Mori, Tsutomu Sasaki
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Patent number: 7071229Abstract: This invention provides an improved process for producing corosolic acid starts from ursolic acid, which occurs in plants in relatively large amounts, the method comprising the steps of oxidizing the hydroxyl group at 3-position and utilizing the carbonyl group at 3-position to introduce a hydroxyl group stereospecifically into the 3-oxoursolic acid at the 2?-position adjacent to the hydroxyl group at 3-position.Type: GrantFiled: June 15, 2004Date of Patent: July 4, 2006Assignee: Tokiwa, Phytochemical Co., Ltd.Inventors: Hiromitsu Takayama, Mariko Kitajima, Tomoko Ishizuka, Shujiro Seo
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Patent number: 6737085Abstract: The present invention provides (1) an Apocynum extract containing not less than 4% of flavonoid compounds and is free of hypericin and hyperforin, (2) an antidepressant composition (in the form of a food, dietary supplement or medicine) containing the Apocynum extract, and (3) a method for treating depression using the Apocynum extract.Type: GrantFiled: November 1, 2001Date of Patent: May 18, 2004Assignee: Tokiwa Phytochemical Co., Ltd.Inventors: Sansei Nishibe, Tsutomu Sasaki, Shujiro Seo, Veronika Butterweck