Patents Assigned to Tokyo Medical and Dental University
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Publication number: 20250120614Abstract: An acquisition unit acquires image data indicating at least a chest and an abdomen of a test subject. A detection unit detects the displacement of each of the chest and abdomen of the test subject by using the image data. A display control unit performs control so that the movement image of each of the chest and abdomen is displayed based on the detected displacement of the chest and abdomen. When the movement of the chest and the movement of the abdomen are synchronized with each other, the display control unit performs control so that the display form of the chest movement image and the display form of the abdomen movement image are the same as each other.Type: ApplicationFiled: July 25, 2022Publication date: April 17, 2025Applicants: NEC Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Makoto YASUKAWA, Yuji OHNO, Yuki KOSAKA, Hirofumi TAKASE, Junpei KATOU, Akimoto NIMURA, Koji FUJITA, Takuya IBARA
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Publication number: 20250107750Abstract: To provide a posture evaluation apparatus, a posture evaluation system, a posture evaluation method, and a program that are capable of suitably evaluating a backward-bending posture. The posture evaluation apparatus according to the present disclosure calculates a feature including at least a feature of an inclination of a head relative to a trunk, based on body information including information indicating at least an inclination of the trunk and an inclination of the head in a body of a subject person in a backward-bending posture in which the subject person is bent backward, and estimates a state of at least a spine in the backward-bending posture, based on the calculated feature.Type: ApplicationFiled: September 23, 2024Publication date: April 3, 2025Applicants: NEC CORPORATION, National University Corporation Tokyo Medical and Dental UniversityInventors: Shuhei NOYORI, Makoto YASUKAWA, Keisuke SUZUKI, Yuki KOSAKA, Akimoto NIMURA, Koji FUJITA, Takuya IBARA
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Patent number: 12263194Abstract: A Bacillus bacterium that induces the production of interleukin-22 is provided. The Bacillus bacterium that induces the production of interleukin-22.Type: GrantFiled: March 16, 2023Date of Patent: April 1, 2025Assignees: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi
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Patent number: 12253515Abstract: Provided are an expression inhibitor of a cancer promoting factor based on the discovery of a new factor influencing the expression amount/level of a cancer promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for cancer. More specifically provided are: an expression inhibitor of a cancer promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS expression inhibitor and RBMS function inhibitor; a screening method using as an indicator the expression or the function of RBMS; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS gene expression and cancer detection method using as an indicator RBMS gene expression amount/level.Type: GrantFiled: November 9, 2018Date of Patent: March 18, 2025Assignees: National University Corporation Tokyo Medical and Dental University, Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Hiroshi Asahara, Tomoki Chiba, Kentaro Abe
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Patent number: 12251491Abstract: Provided is a thrombin-carrying hemostatic sheet that is suitable for hemostasis during surgery, in particular, for hemostasis during spine surgery, that is convenient without preparation before use, and that is bioabsorbable and can be embedded in the body as it is. The hemostatic sheet is composed of a gelatin sponge carrying an effective amount of thrombin, wherein (A) the density is 30 to 55 mg/cm3, and (B) the shape maintaining angle in wet conditions is 55 to 120°.Type: GrantFiled: March 19, 2020Date of Patent: March 18, 2025Assignees: Astellas Pharma Inc., National University Corporation Tokyo Medical and Dental UniversityInventors: Makoto Ogino, Keiichi Yoshihara, Yasuharu Kimura, Megumi Aoki, Toshitaka Yoshii, Satoru Egawa
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CELL POPULATION COMPRISING MESENCHYMAL STEM CELLS, CELL SHEET, AND METHOD FOR PRODUCING A CELL SHEET
Publication number: 20250051728Abstract: The present invention is directed to obtaining a cell population comprising mesenchymal stem cells that are excellent in proliferative capability and osteoblastic differentiation capability and are useful for the regeneration of periodontal tissues. The present invention is also directed to providing a cell sheet and a method for producing a cell sheet, comprising, as a material, a cell population comprising mesenchymal stem cells that are excellent in proliferative capability and osteoblastic differentiation capability and are useful for the regeneration of periodontal tissues. A cell population having alkaline phosphatase activity before calcification induction of 1 U or more is selected and obtained from a cell population comprising mesenchymal stem cells derived from a dental or periodontal tissue.Type: ApplicationFiled: November 16, 2022Publication date: February 13, 2025Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Takanori IWATA, Satoru ONIZUKA -
Publication number: 20250017606Abstract: A guide device that guides a drill that drills a second bone hole in a bone in which a first bone hole is formed includes: an elongated protective portion that is inserted into the first bone hole and that defines, in an interior of the first bone hole, a pathway that extends in a longitudinal direction of the first bone hole and through which a suture passes; a guide portion that has a guide hole that specifies a guide axis and that guides the drill passing through the guide hole along the guide axis; and an arm portion that connects the protective portion with the guide portion. The guide axis is disposed at a twist position with respect to the protective portion, and the drill guided along the guide axis passes through a position at which the drill does not interfere with the suture that passes through the pathway.Type: ApplicationFiled: July 22, 2024Publication date: January 16, 2025Applicants: OLYMPUS TERUMO BIOMATERIALS CORP., National University Corporation Tokyo Medical and Dental UniversityInventors: Tomohiko FUKUHARA, Toshihisa IWANAGA, Hideyuki KOGA
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Publication number: 20250000919Abstract: A composition comprising an ingredient that is effective for inducing autophagy in intestinal epithelial cells and intestinal epithelial stem cells and can be ingested at ease on a daily basis is provided. A composition for inducing autophagy, the composition comprising bacterial cells of a lactic acid bacterium belonging to the family Lactobacillaceae is provided. The lactic acid bacterium is preferably a lactic acid bacterium belonging to any of the genera Lactiplantibacillus, Lactobacillus, Lacticaseibacillus, Companilactobacillus, and Limosilactobacillus.Type: ApplicationFiled: July 12, 2022Publication date: January 2, 2025Applicants: National University Corporation Tokyo Medical and Dental University, MEIJI CO., LTD.Inventors: Shigeomi SHMIZU, Yumiko WATANABE, Toshihiro SASHIHARA
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Patent number: 12161409Abstract: A medical diagnostic apparatus includes a receiver circuit that receives three-dimensional data of an eye, and processing circuitry configured to segment the three-dimensional data into regions that include a target structural element and regions that do not include the target structural element to produce a segmented three-dimensional data set. The segmenting is performed using a plurality of segmentation algorithms. Each of the plurality of segmentation algorithms is trained separately on different two-dimensional data extracted from the three-dimensional data. The processing circuitry is further configured to generate at least one metric from the segmented three-dimensional data set, and evaluate a medical condition based on the at least one metric.Type: GrantFiled: February 11, 2022Date of Patent: December 10, 2024Assignees: TOPCON CORPORATION, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Zaixing Mao, Kyoko Ohno-Matsui, Hiroyuki Takahashi, Noriko Nakao
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Patent number: 12114979Abstract: A biomagnetic field measurement processing apparatus includes circuitry; and a memory storing computer-executable instructions that cause the circuitry to execute reconfiguring a current signal from a biomagnetic field signal; extracting a current component from the current signal; and based on the extracted current component, adding to each other at least two current waveforms among current waveforms of a plurality of inward currents that are current components directed toward a nerve axon from around the nerve axon, or adding to each other at least two current waveforms among current waveforms of a plurality of inward currents that are current components directed toward a muscle fiber from around the muscle fiber, and generating a current waveform to be displayed on a display device, according to the at least two current waveforms added to each other.Type: GrantFiled: May 17, 2022Date of Patent: October 15, 2024Assignees: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental UniversityInventors: Koki Ishida, Taishi Watanabe, Shigenori Kawabata, Jun Hashimoto
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Publication number: 20240315651Abstract: A biometric apparatus including an irradiation device configured to deliver radiation to a subject, a radiation detector configured to perform radiation imaging on a test site of the subject, and a magnetic detector configured to detect biomagnetism of the subject, the magnetic detector being placed between the radiation detector and the irradiation device.Type: ApplicationFiled: March 18, 2024Publication date: September 26, 2024Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental UniversityInventors: Ryoji TAKEDA, Yoshihisa NAIJO, Akira KINOSHITA, Yoshinori OKADA, Shigenori KAWABATA
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Publication number: 20240315649Abstract: A biometric information display device includes circuitry, and a memory storing computer-executable instructions that cause the circuitry to display at least one biological signal waveform including a biological signal measured, and display a graphic representation representing a noise level included in the biological signal waveform at a location corresponding to a peak of the biological signal waveform.Type: ApplicationFiled: March 18, 2024Publication date: September 26, 2024Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental UniversityInventors: Yuki Miyano, Taishi Watanabe, Shigenori Kawabata
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Publication number: 20240316250Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.Type: ApplicationFiled: June 5, 2024Publication date: September 26, 2024Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, SAPPORO MEDICAL UNIVERSITY, ADEKA CORPORATION, KM Biologics Co., Ltd.Inventors: Junichi MATSUDA, Sumika MIYABASHIRA, Satomi HARANO, Akio KISHIDA, Tsuyoshi KIMURA, Jun NEGISHI, Tetsuya HIGAMI, Seiichi FUNAMOTO, Ken-Ichiro HIWATARI, Akiko TASAKI
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Publication number: 20240309059Abstract: Provided is a peptide capable of binding to a receptor binding domain (RBD) in SARS-CoV-2. chemically synthesized easily, having extremely high solubility to ultra-pure water or a buffer solution and a high possibility of being put to practical use as a therapeutic drug for COVID-19.Type: ApplicationFiled: July 6, 2022Publication date: September 19, 2024Applicants: National University Corporation Tokyo Medical and Dental University, CeSPIA Inc.Inventors: Yoshinori FUJIYOSHI, Shun NAKAMURA, Risa NOMURA, Yukihiro TANIMURA, Akiko KAMEGAWA, Nobutaka NUMOTO
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Publication number: 20240299459Abstract: An object of the present invention is to provide a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having a molecule essential for joint medical treatment, and a production method for the therapeutic agent for arthrosis. According to the present invention, there is provided a therapeutic agent for arthrosis, which contains synovium-derived mesenchymal stem cells having any one or more kinds of surface antigens of integrin ?1 or platelet-derived growth factor receptor ?.Type: ApplicationFiled: February 28, 2024Publication date: September 12, 2024Applicants: FUJIFILM Corporation, National University Corporation Tokyo Medical and Dental UniversityInventors: Tsukasa KITAHASHI, Ryo KOGAWA, Kentaro NAKAMURA, Ichiro SEKIYA
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Patent number: 12066429Abstract: Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.Type: GrantFiled: June 26, 2020Date of Patent: August 20, 2024Assignees: National University Corporation Tokyo Medical and Dental University, Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Hiroshi Asahara, Tomoki Chiba, Kentaro Abe
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Publication number: 20240240048Abstract: A polyrotaxane represented by Formula (1): wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500, is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—NH2, and X is a divalent organic group.Type: ApplicationFiled: November 22, 2021Publication date: July 18, 2024Applicants: DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Ruriko AOYAMA SEKIYA, Yoshinori ARISAKA, Nobuhiko YUI, Takanori IWATA, Tetsuya YODA, Masahiro HAKARIYA, Hiroki MASUDA
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Publication number: 20240240183Abstract: A problem to be solved by the present invention is to provide a double-stranded nucleic acid complex having a reduced toxicity whose effectiveness is not impaired. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein: said first nucleic acid strand is capable of hybridizing to at least part of a target gene or a transcription product thereof, and has an antisense effect on said target gene or transcription product thereof, said second nucleic acid strand comprises a base sequence complementary to said first nucleic acid strand, and said first nucleic acid strand and/or said second nucleic acid strand comprises at least one bridged non-natural nucleoside represented by formula (I) or formula (II) (wherein R represents a hydrogen atom or a methyl group).Type: ApplicationFiled: May 24, 2022Publication date: July 18, 2024Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, OSAKA UNIVERSITYInventors: Takanori YOKOTA, Tetsuya NAGATA, Kotaro YOSHIOKA, Satoshi OBIKA
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Publication number: 20240228972Abstract: An object of the present invention is to provide an ever-better method for producing sinusoidal endothelial cells. The present invention provides a method for producing sinusoidal endothelial cells from sinusoidal endothelial progenitor cells, the method comprising the step of culturing the sinusoidal endothelial progenitor cells in a medium containing one or more substances selected from the interleukin 6 (IL-6) family, for example, oncostatin M (OSM), interleukin 6 (IL-6), or interleukin 11 (IL-11).Type: ApplicationFiled: April 27, 2022Publication date: July 11, 2024Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company LimitedInventors: Takanori TAKEBE, Norikazu SAIKI
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Publication number: 20240212103Abstract: To provide an information processing apparatus and the like that are capable of dividing an image indicating movement of a subject into a chest region and an abdominal region along anatomical knowledge. The information processing apparatus inputs time-series distance image data acquired by measuring a distance from a subject during a breathing exercise. The apparatus calculates a standard deviation image indicating a standard deviation of values for each pixel in a distance image indicated by the time-series distance image data. The apparatus executes division processing of dividing the standard deviation image into the chest region and the abdominal region of the subject by using a differential value in a direction of an intersection line between a sagittal plane and a frontal plane of the subject with respect to the standard deviation image. The apparatus outputs a result of the division processing by superimposing the result on the standard deviation image.Type: ApplicationFiled: December 21, 2023Publication date: June 27, 2024Applicants: NEC CORPORATION, National University Corporation Tokyo Medical and Dental UniversityInventors: Makoto YASUKAWA, Keisuke SUZUKI, Shuhei NOYORI, Akimoto NIMURA, Koji FUJITA, Takuya IBARA