Patents Assigned to Tokyo Metropolitan Government
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Publication number: 20230024068Abstract: The present invention provides a prophylactic or therapeutic composition for graft-versus-host disease (GVHD). There is provided a prophylactic or therapeutic composition for GVHD, which comprises bacteria belonging to any genus selected from the group consisting of the following genera: Blautia, Clostridium, unclassified Clostridiales, Actinomyces, Parabacteroides, Lachnoclostridium, Bacteroides, Faecalibacterium, unclassified Lachnospiraceae, Roseburia, Ruminococcus, unclassified Firmicutes, Dorea, Phascolarctobacterium, Sutterella, Megamonas, Collinsella, Eubacterium, and Coprococcus, etc., or any combination of bacteria belonging to these genera.Type: ApplicationFiled: November 25, 2020Publication date: January 26, 2023Applicants: JSR CORPORATION, TOKYO METROPOLITAN GOVERNMENT, KEIO UNIVERSITYInventors: Kazuhiko KAKIHANA, Kyoko INAMOTO, Kenya HONDA, Kozue TAKESHITA, Yuuko KIRIDOOSHI
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Patent number: 11371982Abstract: The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.Type: GrantFiled: January 19, 2017Date of Patent: June 28, 2022Assignees: TOSOH CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Yasuyuki Akiyama, Atsushi Morimoto, Toru Futami, Fumiaki Koizumi, Takeshi Sawada
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Patent number: 10788447Abstract: A liquid analyzer is one that performs analysis in a state of being immersed in a flowing analysis target liquid, and in order to simply make a good/bad determination and increase reliability, includes: a sensor adapted to, in a state where a responsive membrane is immersed in the flowing analysis target liquid, sense a predetermined component contained in the analysis target liquid; an analysis mechanism adapted to analyze the analysis target liquid with use of voltage generated in the sensor; and a resistance measurement mechanism adapted to, in the state where the responsive membrane is immersed in the flowing analysis target liquid, apply DC voltage to the responsive membrane to measure the resistance of the responsive membrane.Type: GrantFiled: November 26, 2015Date of Patent: September 29, 2020Assignees: HORIBA ADVANCED TECHNO CO., LTD., HORIBA, LTD., TOKYO METROPOLITAN GOVERNMENTInventors: Akio Nakayama, Rumiko Furuya, Akio Ishii, Yasuto Kaba, Yuichi Ito, Susumu Yamauchi, Hiroaki Murakami, Atsushi Senda
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Publication number: 20190025282Abstract: The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.Type: ApplicationFiled: January 19, 2017Publication date: January 24, 2019Applicants: TOSOH CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Yasuyuki AKIYAMA, Atsushi MORIMOTO, Toru FUTAMI, Fumiaki KOIZUMI, Takeshi SAWADA
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Patent number: 9850649Abstract: A control plate is provided at a preferred position in a storm overflow chamber. An inflow pipe, an intercepting pipe, and an outflow pipe are connected to the storm overflow chamber. A vortex flow type water surface control device for a draining device includes the overflow chamber, and a control plate arranged in front of an opening portion of the intercepting pipe opening to the storm overflow chamber. A relation (1) 0.5 D?X?0.7 D and 0.83 D?Y?1.5 D holds true, or a relation (2) 0.4 D?X?0.5 D and 1.0 D?Y?1.5 D holds true, where D represents an inner diameter of the opening portion, X represents a projection length of the control plate with respect to the opening portion, and Y represents a distance between the control plate and the opening portion. As a result, contaminants enter the intercepting pipe.Type: GrantFiled: December 9, 2011Date of Patent: December 26, 2017Assignees: NIPPON KOEI CO., LTD, TOKYO METROPOLITAN SEWERAGE SERVICE CORPORATION, TOKYO METROPOLITAN GOVERNMENTInventors: Hiromi Watanabe, Hiroshi Komatsu, Shigeki Nishimura, Shigeru Tsukada
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Patent number: 9134313Abstract: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.Type: GrantFiled: June 9, 2009Date of Patent: September 15, 2015Assignees: Tokyo Metropolitan Organization For Medical Research, CRC Inc., Tokyo Metropolitan Government, Trans Genic Inc.Inventors: Masao Kawakita, Kyoko Hiramatsu, Keiichi Takahashi, Naotaka Hamasaki, Koji Yamaguchi, Tsunehisa Kaku, Koichiro Muta, Munechika Enjoji, Seiji Naito, Jun Hayashi, Shoshu Mitsuyama, Hiroyuki Yamashita, Toru Inoue, Masato Kato
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Patent number: 8979432Abstract: In a conventional storm overflow chamber of a combined sewer system, inflowing floating debris do not flow into an intercepting pipe in a rainy weather, and flow out to a public water body, causing a water pollution in the public water body. According to a vortex flow type water surface control device for a draining device of the present invention, a control plate (6) higher than at least a separating weir (1) is provided between an opening of an inflow pipe (2) and an opening of an intercepting pipe (3) in a storm overflow chamber of a combined sewer system. Moreover, a guide wall (7) higher than at least the separating weir (1) is provided along the separating weir between the opening of the inflow pipe (2) and the separating weir (1).Type: GrantFiled: August 2, 2004Date of Patent: March 17, 2015Assignees: Tokyo Metropolitan Government, Tokyo metropolitan Sewerage Service Corporation, Nippon Koei Co., Ltd.Inventors: Ikuo Uemura, Hirofumi Ishiwada, Shouichi Banba, Aya Uchino, Tsuneo Ochiai, Hiroshi Komatsu, Shigeki Nishimura, Shigeru Tukada
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Patent number: 8792977Abstract: The system of the present invention includes (a) means for displaying image information including a target image and a cursor image for tracking the target image; (b) means used when the subject moves the cursor image; (c) means for detecting the state of tracking the target image by the cursor image; (d) means for detecting the muscle active state of the subject using the means (b); (e) means for analyzing the tracking state detected by the means (c) and the muscle active state detected by the means (d); and (f) means for evaluating the motor function of the subject by using results of analysis obtained by the means (e) as indexes.Type: GrantFiled: February 26, 2008Date of Patent: July 29, 2014Assignees: Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan GovernmentInventors: Shinji Kakei, Jongho Lee, Yasuhiro Kagamihara
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Patent number: 8660641Abstract: The present invention provides a system for evaluating motor control function in the brain.Type: GrantFiled: September 15, 2010Date of Patent: February 25, 2014Assignees: Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan GovernmentInventors: Shinji Kakei, Jongho Lee, Yasuhiro Kagamihara
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Patent number: 8632104Abstract: A lock member capable of contacting an engaging projection of an inserted pipe section from a direction of the pipe axis and relatively rotatably attachable between an annular wall portion of a receiving pipe section and the engaging projection of the inserted pipe section includes engaging stopper portions projecting therefrom for contacting an inward surface of the annular wall portion from the direction of the pipe axis. The annular wall portion has attachment/detachment recesses formed therein for allowing inserting and removing movements of the engaging stopper portions in the direction of the pipe axis. An elastic urging member is provided between an extending portion projecting from the lock member to the outside of the pipe through an inner peripheral surface of the annular wall portion and the outer peripheral surface of the inserted pipe section, and an outward surface of the annular wall portion.Type: GrantFiled: November 24, 2005Date of Patent: January 21, 2014Assignees: Tokyo Metropolitan Government, Taisei Kiko Co., Ltd.Inventors: Go Horikawa, Fumiyoshi Miyazaki
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Publication number: 20130240421Abstract: A control plate is provided at a preferred position in a storm overflow chamber. An inflow pipe, an intercepting pipe, and an outflow pipe are connected to the storm overflow chamber. A vortex flow type water surface control device for a draining device includes the overflow chamber, and a control plate arranged in front of an opening portion of the intercepting pipe opening to the storm overflow chamber. A relation (1) 0.5D?X?0.7D and 0.83D?Y?1.5D holds true, or a relation (2) 0.4D?X?0.5D and 1.0D?Y?1.5D holds true, where D represents an inner diameter of the opening portion, X represents a projection length of the control plate with respect to the opening portion, and Y represents a distance between the control plate and the opening portion. As a result, contaminants enter the intercepting pipe.Type: ApplicationFiled: December 9, 2011Publication date: September 19, 2013Applicants: NIPPON KOEI CO., LTD., TOKYO METROPOLITAN GOVERNMENT, TOKYO METROPOLITAN SEWERAGE SERVICE CORPORATIONInventors: Hiromi Watanabe, Hiroshi Komatsu, Shigeki Nishimura, Shigeru Tsukada
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Patent number: 8459900Abstract: A vortex flow type water surface control device for a draining device is provided. The vortex flow type water surface control device may include an inflow pipe, an outflow pipe, an intercepting pipe, and a separating weir that is disposed to block the intercepting pipe and the inflow pipe from the outflow pipe. The vortex flow type water surface control device may also include a control plate that is disposed between an opening of the inflow pipe and an opening of the intercepting pipe. A height of the control plate may be higher than at least a height of the separating weir. The control plate may be apart from the separating weir, and may approximately extend to a center axis of the intercepting pipe.Type: GrantFiled: August 4, 2011Date of Patent: June 11, 2013Assignees: Tokyo Metropolitan Government, Tokyo Metropolitan Sewerage Servce Corporation, Nippon Koei Co., Ltd.Inventors: Ikuo Uemura, Hirofumi Ishiwada, Shouichi Banba, Aya Uchino, Tsuneo Ochiai, Hiroshi Komatsu, Shigeki Nishimura, Shigeru Tukada
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Publication number: 20110284441Abstract: A vortex flow type water surface control device for a draining device is provided. The vortex flow type water surface control device may include an inflow pipe, an outflow pipe, an intercepting pipe, and a separating weir that is disposed to block the intercepting pipe and the inflow pipe from the outflow pipe. The vortex flow type water surface control device may also include a control plate that is disposed between an opening of the inflow pipe and an opening of the intercepting pipe. A height of the control plate may be higher than at least a height of the separating weir. The control plate may be apart from the separating weir, and may approximately extend to a center axis of the intercepting pipe.Type: ApplicationFiled: August 4, 2011Publication date: November 24, 2011Applicants: TOKYO METROPOLITAN GOVERNMENT, NIPPON KOEI CO. LTD., TOKYO METROPOLITAN SEWERAGE SERVICE CORPORATIONInventors: Ikuo UEMURA, Hirofumi ISHIWADA, Shouichi BANBA, Aya UCHINO, Tsuneo OCHIAI, Hiroshi KOMATSU, Shigeki NISHIMURA, Shigeru TUKADA
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Publication number: 20110137196Abstract: The system of the present invention includes (a) means for displaying image information including a target image and a cursor image for tracking the target image; (b) means used when the subject moves the cursor image; (c) means for detecting the state of tracking the target image by the cursor image; (d) means for detecting the muscle active state of the subject using the means (b); (e) means for analyzing the tracking state detected by the means (c) and the muscle active state detected by the means (d); and (f) means for evaluating the motor function of the subject by using results of analysis obtained by the means (e) as indexes.Type: ApplicationFiled: February 26, 2008Publication date: June 9, 2011Applicants: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, TOKYO METROPOLITAN GOVERNMENTInventors: Shinji Kakei, Jongho Lee, Yasuhiro Kagamihara
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Publication number: 20090298098Abstract: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.Type: ApplicationFiled: June 9, 2009Publication date: December 3, 2009Applicants: TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH, CRC Inc., Tokyo Metropolitan Government, Trans Genic Inc.Inventors: Masao KAWAKITA, Kyoko HIRAMATSU, Keiichi TAKAHASHI, Naotaka HAMASAKI, Koji YAMAGUCHI, Tsunehisa KAKU, Koichiro MUTA, Munechika ENJOJI, Seiji NAITO, Jun HAYASHI, Shoshu MITSUYAMA, Hiroyuki YAMASHITA, Toru INOUE, Masato KATO
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Patent number: 7604263Abstract: A pipe joint construction comprising an elastic seal member (4) for hermetically sealing between an inner circumferential surface of a receiving pipe section (1) and an outer circumferential surface of an inserted pipe section (2) inserted into and connected to the receiving pipe section in a pipe axis direction (X), and a lock member (7) provided in the inner circumferential surface of the receiving pipe section (1) adjacent a receiving opening thereof for preventing separation of the pipe sections by contacting an engaging projection (5) protruding from the outer circumferential surface of the inserted pipe section (2) in the pipe axis direction, wherein the construction further comprises an attachment/detachment control device (A) for attaching and detaching the lock member (7) to/from the receiving pipe section (1) by rotating the lock member (7) about the pipe axis direction (X) relative to the receiving pipe section (1) and by moving, in the pipe axis direction (X), the lock member (7) placed in a speciType: GrantFiled: December 15, 2004Date of Patent: October 20, 2009Assignees: Tokyo Metropolitan Government, Taisei Kiko Co., Ltd.Inventors: Mitsuhiro Mori, Fumiyoshi Miyazaki
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Publication number: 20080258463Abstract: A lock member 27 capable of contacting an engaging projection 22 of an inserted pipe section 8 from a direction of pipe axis X2 and relatively rotatably attachable between an annular wall portion 24 of a receiving pipe section 6 and the engaging projection of the inserted pipe section 8 includes engaging stopper portions 27a projecting therefrom for contacting an inward surface of the annular wall portion 24 from the direction of pipe axis X2. The annular wall portion 24 has attachment/detachment recesses 28 formed therein for allowing inserting and removing movements of the engaging stopper portions 27a in the direction of pipe axis X2.Type: ApplicationFiled: November 24, 2005Publication date: October 23, 2008Applicants: TOKYO METROPOLITAN GOVERNMENT, TAISEI KIKO CO., LTDInventors: Go Horikawa, Fumiyoshi Miyazaki
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Publication number: 20080023074Abstract: In a conventional storm overflow chamber of a combined sewer system, inflowing floating debris do not flow into an intercepting pipe in a rainy weather, and flow out to a public water body, causing a water pollution in the public water body. According to a vortex flow type water surface control device for a draining device of the present invention, a control plate (6) higher than at least a separating weir (1) is provided between an opening of an inflow pipe (2) and an opening of an intercepting pipe (3) in a storm overflow chamber of a combined sewer system. Moreover, a guide wall (7) higher than at least the separating weir (1) is provided along the separating weir between the opening of the inflow pipe (2) and the separating weir (1).Type: ApplicationFiled: August 2, 2004Publication date: January 31, 2008Applicants: TOKYO METROPOLITAN GOVERNMENT, TOKYO METROPOLITAN SEWERAGE SERVICE CORPORATION, NIPPON KOEI CO. LTD.Inventors: Ikuo Uemura, Hirofumi Ishiwada, Shouichi Banba, Aya Uchino, Tsuneo Ochiai, Hiroshi Komatsu, Shigeki Nishimura, Shigeru Tukada
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Publication number: 20070158944Abstract: A pipe joint construction comprising an elastic seal member (4) for hermetically sealing between an inner circumferential surface of a receiving pipe section (1) and an outer circumferential surface of an inserted pipe section (2) inserted into and connected to the receiving pipe section in a pipe axis direction (X), and a lock member (7) provided in the inner circumferential surface of the receiving pipe section (1) adjacent a receiving opening thereof for preventing separation of the pipe sections by contacting an engaging projection (5) protruding from the outer circumferential surface of the inserted pipe section (2) in the pipe axis direction, wherein the construction further comprises an attachment/detachment control device (A) for attaching and detaching the lock member (7) to/from the receiving pipe section (1) by rotating the lock member (7) about the pipe axis direction (X) relative to the receiving pipe section (1) and by moving, in the pipe axis direction (X), the lock member (7) placed in a speciType: ApplicationFiled: December 15, 2004Publication date: July 12, 2007Applicants: TOKYO METROPOLITAN GOVERNMENT, TAISEI KIKO CO., LTD.Inventors: Mitsuhiro Mori, Fumiyoshi Miyazaki
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Patent number: 5203901Abstract: A processing method is presented for treating sludges from municipal and waste materials. The ashes from such sludges, containing SiO.sub.2 as a primary constituent, are treated with additives to tailor the feed material composition. Thermal processing, including melting, rapid cooling and subsequent annealing, produces a crystallized glass microstructure in which needle-shaped shaped crystals of anorthite and .beta.-wollastnite are infiltrated with a vitreous material. Such crystallized glasses having superior mechanical and aesthetic properties are an attractive architectural material which can be utilized for interior finishing, exterior walls, flooring as well as for interior decorations.Type: GrantFiled: December 18, 1991Date of Patent: April 20, 1993Assignees: Tsukishima Kikai Co., Ltd., Tokyo Metropolitan GovernmentInventors: Shigeru Suzuki, Keiichiro Miyano, Takumi Kaneko, Yoshikazu Nagayoshi