Patents Assigned to Tokyo Metropolitan Institute for Neuroscience
  • Methods and kits for identifying human arylamine N-acetyltransferase genes
    Patent number: 5527677
    Abstract: The invention provides polymorphic human arylamine N-acetyltransferase (NAT) genes, more precisely a type 1 NAT gene containing the 5'-noncoding region base sequence of SEQ ID NO:1 and the coding region-containing base sequence of SEQ ID NO:2, a type 2 NAT gene containing the sequences of SEQ ID NO:3 and SEQ ID NO:4 and a type 3 NAT gene containing the sequences of SEQ ID NO:5 and SEQ ID NO:6, as well as a method of detecting these polymorphic genes and a method of diagnosing an adverse effect or effects to be caused by an amino-containing aromatic substance.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: June 18, 1996
    Assignees: Tokyo Metropolitan Institute for Neuroscience, Otsuka Pharmaceutical Co., Ltd.
    Inventors: Takeo Deguchi, Moritoshi Kinoshita, Kiyonori Katsuragi, Sadahito Shin
  • Glutamate receptor inhibitor
    Patent number: 5246968
    Abstract: A compound having glutamate receptor inhibitor activity represented by the formula: ##STR1## where R represents a hydrogen atom or a group of the formula: ##STR2## m and n each represents an integer of 3 or 4 and p represents an integer of 0 or 1, or a salt thereof is provided. The compounds are useful for an insecticide.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 21, 1993
    Assignees: Takeda Chimical Industries, Ltd., Tokyo Metropolitan Institute for Neurosciences
    Inventors: Terumi Nakajima, Yoshio Aramaki, Tadashi Yasuhara, Tsutomu Higashijima, Nobufumi Kawai, Akiko Miwa, Masanori Yoshioka
  • Recombinant baculovirus
    Patent number: 5229293
    Abstract: Recombinant Baculovirus in which the cDNA encoding E protein derived from Japanese encephalitis virus is integrated into the genome region non-essential to proliferation of Baculovirus under control of the promoter is infected to insect cells such as Sf9 cells, derived from Spodoptera frugiperda and the infected cells are cultured to express E protein of Japanese encephalitis. This E protein is useful as vaccines or diagnostics.
    Type: Grant
    Filed: May 5, 1989
    Date of Patent: July 20, 1993
    Assignees: Nippon Zeon Co Ltd., Tokyo Metropolitan Institute for Neurosciences, Yoshiharu Matsuura
    Inventors: Yoshiharu Matsuura, Kotaro Yasui, Takanori Sato
  • Recombinant vaccinia virus expressing E-protein of Japanese encephalitis virus
    Patent number: 5021347
    Abstract: There is provided a recombinant vaccinia virus having inserted cDNA coding for E-protein of Japanese encephalitis virus into a genome region non-essential to growth of a vaccinia virus, in the form of capable expression. The recombinant vaccinia virus is useful as a live vaccine.
    Type: Grant
    Filed: September 15, 1988
    Date of Patent: June 4, 1991
    Assignees: Nippon Zeon Co., Ltd., Director-General of National Institute of Health, Tokyo Metropolitan Institute for Neuroscience
    Inventors: Kotaro Yasui, Asato Kojima, Atsushi Yasuda, Takanori Sato
  • Glutamate receptor inhibitor and insecticidal composition
    Patent number: 4918107
    Abstract: A compound of the formula ##STR1## wherein R' is hydrogen atom or an alkyl group, m is an integer of 1 to 3, p is 1 or 2, x is an integer of 2 to 6, and y is an integer of 1 to 3, or a salt thereof, which has glutamate receptor inhibitor activity, a process for preparing the same and an insecticidal composition containing the same are provided.
    Type: Grant
    Filed: June 6, 1988
    Date of Patent: April 17, 1990
    Assignees: Tsumura & Co., Tokyo Metropolitan Institute for Neurosciences, Takeda Chemical Industries, Ltd.
    Inventors: Terumi Nakajima, Nobufumi Kawai, Koichi Shudo, Tetsuo Shiba
  • Glutamate receptor inhibitor
    Patent number: 4855405
    Abstract: A novel glutamate receptor inhibitor obtained from Joro spider venom glands, and its manufacturing method.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: August 8, 1989
    Assignees: Tokyo Metropolitan Institute for Neurosciences, Takeda Chemical Industries, Ltd.
    Inventors: Masanori Yoshioka, Hidemitsu Hou, Nobufumi Kawai