Patents Assigned to Tomita Pharmaceutical Co., Ltd.
  • Patent number: 11124420
    Abstract: Provided is powdered gyrolite-type calcium silicate that has a relatively large particle size, yet is endowed with both a high oil absorption and a high particle strength. The powdered gyrolite-type calcium silicate has (1) an oil absorption of at least 2.8 mL/g, (2) an average particle diameter of at least 40 ?m, and (3) in treatment where the gyrolite-type calcium silicate is charged into a laser diffraction-type particle size analyzer within the range of a diffraction volume of from 0.1 to 0.6 and circulated at a flow rate of 32.5 mL/s for 5 minutes, a percent change in average particle diameter following treatment with respect to average particle diameter before treatment of 15% or less.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: September 21, 2021
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Yuuta Tsumura, Kazuki Kamai, Yukinori Konishi, Kazuhiko Tamagawa
  • Patent number: 10793696
    Abstract: An object of the present invention is to provide a polyolefin composition prepared by kneading a hygroscopic inorganic filler into a polyolefin, without substantially using an additive such as a dispersant or an antioxidant, the polyolefin composition having good dispersibility of the hygroscopic inorganic filler as well as excellent moldability. By kneading anhydrous magnesium sulfate as a hygroscopic inorganic filler into a polyolefin, without substantially adding an additive such as a dispersant or an antioxidant, and by setting the moisture content in the kneaded product to 0.1 wt % or less, a polyolefin composition having good dispersibility of anhydrous magnesium sulfate as well as excellent moldability can be obtained.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: October 6, 2020
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Hideyuki Aoyama, Yoshiyasu Bando, Masanori Sumi, Masaya Uemoto, Makoto Fujii, Seiji Sato
  • Patent number: 10531684
    Abstract: Provided is a powder containing ferric pyrophosphate that affords high iron absorbability, as a main component of an oral iron preparation. The present invention relates to a composite powder containing ferric pyrophosphate, which is a powder containing ferric pyrophosphate and a sodium component, wherein (1) the content of ferric pyrophosphate is 95 wt % or higher, and (2) a (Fe+Na)/P molar ratio is 0.8 to 1.0.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: January 14, 2020
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Sadayoshi Watanabe, Yukinori Konishi, Shota Minami, Akihito Bando, Naoyuki Kitamura
  • Patent number: 10525078
    Abstract: A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: January 7, 2020
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Michiko Myose, Hiroshi Noguchi, Junya Kikuishi, Hideyuki Aoyama, Mina Hashimoto, Yusuke Yoshimoto
  • Patent number: 10517825
    Abstract: Provided is a powder composition containing an oily substance, the powder composition having good oxidation stability and excellent compression moldability. The powder composition containing an oily substance contains a powdery calcium silicate-based material, and an oily substance impregnated into the material. In the material, a cumulative pore volume for a pore size of 10 to 70 nm is 1.1 cc/g or more, and a cumulative pore volume for a pore size of 70 to 500 nm is 2.0 cc/g or less.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: December 31, 2019
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Takanori Taniwaki, Kazuki Kamai, Yuuta Tsumura, Daichi Masaki
  • Patent number: 10292913
    Abstract: Provided is a powdered tobermorite-type calcium silicate-based material capable of demonstrating high oil absorption. The powdered tobermorite-type calcium silicate-based material is characterized in that (1) a molar ratio of SiO2/CaO in the material is 1.5 or more, and (2) a cumulative pore volume having a pore size of 3.6 nm to 200 nm in the material is 0.9 cc/g or more, and a cumulative pore volume having a pore size of 3.6 nm to 5000 nm is 2.6 cc/g or more.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 21, 2019
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Yuka Okada, Kazuki Kamai, Yuuta Tsumura, Yukinori Konishi
  • Patent number: 10251988
    Abstract: A dialysis agent A including a mixture containing glucose, acetic acid, and acetate salt, but not sodium bicarbonate, wherein the molar ratio of acetic acid:acetate salt is 1:0.5 to 1:2, and wherein a total amount of the acetic acid and acetate salt contained in the dialysis agent A is between 2 mEq/L and 6 mEq/L when the dialysis agent A is dissolved in 1 L of a bicarbonate dialysate.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: April 9, 2019
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Noguchi, Michiko Myose, Junya Kikuishi, Mina Hashimoto, Hideyuki Aoyama
  • Publication number: 20180236433
    Abstract: A magnesium sulfate-based desiccant comprising powder composed of coated particles that contain a particle of magnesium sulfate represented by the chemical formula MgSO4.nH2O (0?n?3) and a coating layer on the surface of the particle, wherein: (1) the coating layer contains a coating material that is at least one of carboxylic acids and salts thereof; (2) the powder has an average particle diameter of 5 ?m or less; and (3) a contact angle of water relative to the face formed with the powder is 20 degrees or more, and to a method for producing the same.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 23, 2018
    Applicant: Tomita Pharmaceutical Co., Ltd.
    Inventors: Kazuhito Kayama, Koh Konishi, Masahiro Hitomi, Minoru Kometani, Masashi Konishi, Ariumi Kawamoto
  • Patent number: 9931453
    Abstract: The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt, and include acetic acid and acetate salt in a total amount of between 2 mEq or more and less than 6 mEq in the dialysis agent A required to prepare 1 L of the bicarbonate dialysate.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: April 3, 2018
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Hiroshi Noguchi, Michiko Myose, Junya Kikuishi, Mina Hashimoto, Hideyuki Aoyama
  • Patent number: 9463266
    Abstract: Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: October 11, 2016
    Assignee: Tomita Pharmaceuticals Co., Ltd.
    Inventors: Hiroshi Noguchi, Junya Kikuishi, Hideyuki Aoyama, Mina Hashimoto
  • Patent number: 9149434
    Abstract: The present invention provides a core particle for a pharmaceutical preparation which features the requisite properties of a core particle, and which has enough chemical stability, and in which reactivity with the drug (an active pharmaceutical ingredient) is limited or prevented. More specifically, the present invention relates to a core particle wherein a film containing an active pharmaceutical ingredient can be formed on the surface thereof, and (1) the core particle comprises a pharmaceutically acceptable inorganic material, (2) the inorganic material is poorly soluble in water, and (3) pH of a solution of the inorganic material is 5 to 8.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: October 6, 2015
    Assignee: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto, Kanako Hattori
  • Patent number: 8980330
    Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: March 17, 2015
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
  • Publication number: 20140171571
    Abstract: The present invention is to provide a magnesium sulfate-based desiccant comprising powder composed of coated particles that contain a particle of magnesium sulfate represented by the chemical formula MgSO4.nH2O (0?n?3) and a coating layer on the surface of the particle, wherein: (1) the coating layer contains a coating material that is at least one of carboxylic acids and salts thereof; (2) the powder has an average particle diameter of 5 ?m or less; and (3) a contact angle of water relative to the face formed with the powder is 20 degrees or more, and to a method for producing the same.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 19, 2014
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhito Kayama, Koh Konishi, Masahiro Hitomi, Minoru Kometani, Masashi Konishi, Ariumi Kawamoto
  • Publication number: 20140097386
    Abstract: The purpose of the present invention is to provide a dialysis agent A, which is able to set the total acetate ion content in the dialysate to a low value, excellent in storage stability of glucose, able to reduce the acetic acid odor, and able to suppress the corrosion of the dialysate delivery system and the dialysis machine, as well as to provide a two pack type dialysis agent utilizing the dialysis agent A. In the dialysis agent A used in the preparation of a bicarbonate dialysate, which is used as one part of a two pack type dialysis agent, it becomes possible to prepare a bicarbonate dialysate having the total acetate ion concentration of between 2 mEq/L or more and less than 6 mEq/L by allowing to include glucose, acetic acid and acetate salt and to satisfy the molar ratio of 1:0.5 to 2 of acetic acid and acetate salt, and include acetic acid and acetate salt in a total amount of between 2 mEq or more and less than 6 mEq in the dialysis agent A required to prepare 1 L of the bicarbonate dialysate.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: Tomita Pharmaceutical Co., Ltd.,
    Inventors: Hiroshi NOGUCHI, Michiko MYOSE, Junya KIKUISHI, Mina HASHIMOTO, Hideyuki AOYAMA
  • Patent number: 8679547
    Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: March 25, 2014
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
  • Patent number: 8668852
    Abstract: The present invention provides a powder for molding that reduces or prevents drawbacks such as unevenness and low fluidity when a mixed powder is used as a powder for molding. The present invention relates to powders for molding including particles in which each particle contains an inorganic component and a water-soluble organic polymer component and methods for producing the same.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: March 11, 2014
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Akira Ookubo, Tomohide Koizumi, Kazuma Tamura
  • Publication number: 20130168316
    Abstract: Technology for preparing a dialysis fluid capable of flexibly changing bicarbonate ion concentration and maintaining concentrations of electrolytes such as potassium, calcium, and magnesium at constant levels during dialysis according to the disease state of a patient. A three-component dialysate containing an agent S containing sodium chloride, an agent B containing sodium bicarbonate, and an agent A containing electrolyte components other than sodium chloride and sodium bicarbonate, with suitable adjustment of the amount of the agent B during dialysis fluid preparation maintains concentrations of trace metal ions such as potassium ions, calcium ions, and magnesium ions in a dialysis fluid at constant levels and flexibly changes the bicarbonate ion concentration therein. Adjusting the ratio between the amount of the agent S and agent B when the dialysate is used also makes it possible to maintain the sodium ion concentration at a constant level or flexibly change the sodium ion concentration.
    Type: Application
    Filed: December 27, 2012
    Publication date: July 4, 2013
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventor: TOMITA PHARMACEUTICAL CO., LTD.
  • Publication number: 20130171270
    Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.
    Type: Application
    Filed: February 27, 2013
    Publication date: July 4, 2013
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventor: Tomita Pharmaceutical Co., Ltd.
  • Publication number: 20130101685
    Abstract: Provided is a method that enables a calcium silicate-based material to be produced more efficiently. The method of producing a calcium silicate-based material comprises: (1) a step of obtaining a reaction product by reacting raw materials containing a calcium component, a silicon component and an aluminum component in an aqueous medium; and (2) a step of forming calcium silicate by subjecting the reaction product to hydrothermal treatment.
    Type: Application
    Filed: October 20, 2011
    Publication date: April 25, 2013
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Koh Konishi, Yuta Tsumura, Seiki Shinomiya, Masashi Konishi, Yukinori Konishi
  • Publication number: 20130059151
    Abstract: Provided is a magnesium oxide for pharmaceutical use that, when mixed with a drug that is unstable in acid, demonstrates high stabilizing effects on the drug while also demonstrating superior stability of the magnesium oxide per se. The magnesium oxide for pharmaceutical use is used by being mixed with a drug that is unstable in acid, and has a specific surface area as determined according to the BET method of 20 m2/g to 200 m2/g and a degree of activation of 40 Img/g to 200 Img/g.
    Type: Application
    Filed: October 20, 2011
    Publication date: March 7, 2013
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto