Patents Assigned to Tomita Pharmaceuticals Co., Ltd.
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Publication number: 20130059151Abstract: Provided is a magnesium oxide for pharmaceutical use that, when mixed with a drug that is unstable in acid, demonstrates high stabilizing effects on the drug while also demonstrating superior stability of the magnesium oxide per se. The magnesium oxide for pharmaceutical use is used by being mixed with a drug that is unstable in acid, and has a specific surface area as determined according to the BET method of 20 m2/g to 200 m2/g and a degree of activation of 40 Img/g to 200 Img/g.Type: ApplicationFiled: October 20, 2011Publication date: March 7, 2013Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto
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Patent number: 8186415Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.Type: GrantFiled: April 8, 2011Date of Patent: May 29, 2012Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
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Publication number: 20120018915Abstract: The present invention provides a powder for molding that reduces or prevents drawbacks such as unevenness and low fluidity when a mixed powder is used as a powder for molding. The present invention relates to powders for molding including particles in which each particle contains an inorganic component and a water-soluble organic polymer component and methods for producing the same.Type: ApplicationFiled: February 26, 2010Publication date: January 26, 2012Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Akira Ookubo, Tomohide Koizumi, Kazuma Tamura
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Publication number: 20110186257Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.Type: ApplicationFiled: April 8, 2011Publication date: August 4, 2011Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
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Patent number: 7942187Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.Type: GrantFiled: December 19, 2006Date of Patent: May 17, 2011Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
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Publication number: 20110059247Abstract: [Object] To form a modeled object with high accuracy. [Solving Means] A powder transfer mechanism (16) laminates powder layers containing water-soluble powder as a main component one by one at a modeling portion (14). An inkjet line head (17) injects a water-based ink that dissolves the powder in an area of an uppermost layer of the powder layers laminated by the powder transfer mechanism (16), the area corresponding to a cross-sectional shape of a modeled object. Then, a heater (18) heats the powder for each layer of the powder layers. Further, the heater (18) heats the powder after the water-based ink is injected by the inkjet line head (17) or before the water-based ink is injected by the inkjet line head (17). The present invention can be applied to a modeling apparatus, for example.Type: ApplicationFiled: May 14, 2009Publication date: March 10, 2011Applicants: Sony Corporation, Tomita Pharmaceutical Co., Ltd.Inventors: Junichi Kuzusako, Masanobu Yamamoto, Akira Ookubo, Toshihiro Kamewa, Tomohide Koizumi, Kazuma Tamura, Takeshi Matsui
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Publication number: 20100260856Abstract: The present invention provides a core particle for a pharmaceutical preparation which features the requisite properties of a core particle, and which has enough chemical stability, and in which reactivity with the drug (an active pharmaceutical ingredient) is limited or prevented. More specifically, the present invention relates to a core particle wherein a film containing an active pharmaceutical ingredient can be formed on the surface thereof, and (1) the core particle comprises a pharmaceutically acceptable inorganic material, (2) the inorganic material is poorly soluble in water, and (3) pH of a solution of the inorganic material is 5 to 8.Type: ApplicationFiled: September 8, 2008Publication date: October 14, 2010Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto, Kanako Hattori
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Publication number: 20090008055Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.Type: ApplicationFiled: December 19, 2006Publication date: January 8, 2009Applicant: TOMITA PHARMACEUTICAL CO., LTD.Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
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Patent number: 7473300Abstract: A moisture absorbent composition is provided with a thermoplastic resin; and a moisture absorbent kneaded into the thermoplastic resin, having a secondary particle size of substantially 1 to 40 ?m, wherein equilibrium humidity is controlled by selecting the specific gravity of the thermoplastic resin. A method for controlling equilibrium humidity in a moisture absorbent composition obtained by kneading a moisture absorbent into a thermoplastic resin is provided, which includes kneading the moisture absorbent such that a secondary particle size of the moisture absorbent is substantially 1 to 40 ?m; and controlling equilibrium humidity by selecting specific gravity of the thermoplastic resin.Type: GrantFiled: November 28, 2006Date of Patent: January 6, 2009Assignees: Sasaki Chemicals Co., Ltd., Tomita Pharmaceutical Co., Ltd.Inventors: Katsuhiko Uegaki, Toru Sakiyama
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Publication number: 20010019727Abstract: A biocidal material comprising, as an active ingredient, a compound represented by General Formula (1)Type: ApplicationFiled: December 13, 2000Publication date: September 6, 2001Applicant: Secretary, Agency of Industrial Science and Technology & Tomita Pharmaceutical Co., Ltd.Inventors: Yoji Makita, Osamu Ikai, Kenta Ooi, Akinari Sonoda, Masahito Taya, Motomu Nishioka, Akira Ookubo, Mikiko Mihara
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Patent number: 6132624Abstract: A method for treating phosphate-containing waste water comprising treating phosphate-containing waste water with a metal hydroxide complex as a phosphate adsorbent represented by formula (1):M.sub.1-x.sup.2+ M.sub.x.sup.3+ (OH.sup.-).sub.2+x-y (A.sup.n-).sub.y/n(1)wherein M.sup.2+ represents at least one divalent metal ion selected from the group consisting of Mg.sup.2+, Ni.sup.2+, Zn.sup.2+, Fe.sup.2+, Ca.sup.2+ and Cu.sup.2+, M.sup.3+ represents at least one trivalent metal ion selected from the group consisting of Al.sup.3+ and Fe.sup.3+, A.sup.n- represents n-valent anion, 0.1.ltoreq.x.ltoreq.0.5, 0.1.ltoreq.y.ltoreq.0.5 and n is 1 or 2 to adsorb phosphate is provided.Type: GrantFiled: October 21, 1998Date of Patent: October 17, 2000Assignee: Tomita Pharmaceutical Co. LTDInventors: Takashi Suzuki, Toshio Sato, Akira Ookubo, Tomohide Koizumi, Mikiko Mihara, Shouichi Oonishi
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Patent number: 6013238Abstract: This invention aims to provide titanate whiskers which are excellent in heat resistance, chemical resistance and reinforcing effect and are low in coefficient of thermal conductivity.The titanate whiskers of the invention are those represented by the formulaA.sup.I.sub.v A.sup.II.sub.w M.sup.II.sub.x M.sup.III.sub.y Ti.sub.8-z O.sub.16wherein A.sup.I is at least one member selected from alkali metals, A.sup.II is Ba, M.sup.II is at least one member selected from the group consisting of Mg, Co, Ni, Zn, Cu and Mn, M.sup.III is at least one member selected from the group consisting of Al, Sc, Cr, Fe and Ga, and v, w, x, y and z are real numbers which fulfill 0.5.ltoreq.2x+y.ltoreq.2.5, 2x+y=v+2w, and z=x+y.Type: GrantFiled: July 2, 1998Date of Patent: January 11, 2000Assignees: Otsuka Kagaku Kabushiki Kaisha, Tomita Pharmaceutical Co., Ltd.Inventors: Hiroki Murata, Masayoshi Suzue, Akiyoshi Kawaguchi, Fauzi Faustinus, Toshihiro Kamewa, Tomohide Koizumi
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Patent number: 5976401Abstract: A method for treating phosphate-containing waste water comprising treating phosphate-containing waste water with a metal hydroxide complex as a phosphate adsorbent represented by the formula:M.sub.1-x.sup.2+ M.sub.x.sup.3+ (OH.sup.-).sub.2+x-y (A.sup.n-).sub.y/nwherein M.sup.2+ is at least one divalent metal ion selected from the group consisting of Mg.sup.2+, Ni.sup.2+, Zn.sup.2+, Fe.sup.2+, Ca.sup.2+ and Cu.sup.2+ ; M.sup.3+ is at least one divalent metal ion selected from the group consisting of Al.sup.3+ and Fe.sup.3+ ; A.sup.n- is an n-valent anion; x is in the range 0.1.ltoreq.x.ltoreq.0.5; y is in the range 0.1.ltoreq.y.ltoreq.0.5; and n is 1 or 2.Type: GrantFiled: August 6, 1997Date of Patent: November 2, 1999Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Takashi Suzuki, Toshio Sato, Akira Ookubo, Tomohide Koizumi, Mikiko Mihara, Shoichi Oonishi
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Patent number: 5942205Abstract: This invention aims to provide titanate whiskers which are excellent in heat resistance, chemical resistance and reinforcing effect and are low in coefficient of thermal conductivity.The titanate whiskers of the invention are those represented by the formulaA.sup.I.sub.v A.sup.II.sub.w M.sup.II.sub.x M.sup.III.sub.y Ti.sub.8-z O.sub.16wherein A.sup.I is at least one member selected from alkali metals, A.sup.II is Ba, M.sup.II is at least one member selected from the group consisting of Mg, Co, Ni, Zn, Cu and Mn, M.sup.III is at least one member selected from the group consisting of Al, Sc, Cr, Fe and Ga, and v, w, x, y and z are real numbers which fulfill 0.5.ltoreq.2x+y.ltoreq.2.5, 2x+y=v+2w, and z=x+y.Type: GrantFiled: February 10, 1997Date of Patent: August 24, 1999Assignees: Otsuka Kagaku Kabushiki Kaisha, Tomita Pharmaceutical Co., Ltd.Inventors: Hiroki Murata, Masayoshi Suzue, Akiyoshi Kawaguchi, Fauzi Faustinus, Toshihiro Kamewa, Tomohide Koizumi
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Patent number: 5674715Abstract: A method for producing uridine diphosphate N-acetylglucosamine comprising culturing osmo-tolerant yeasts in aerobic conditions in a medium having inorganic salt concentration of about 2-8%.Type: GrantFiled: May 5, 1995Date of Patent: October 7, 1997Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Minoru Tomita, Hisao Mukai
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Patent number: 5540842Abstract: A granular to fine-granular dry mix powder (an artificial kidney perfusion component A of uniform composition) for use in the preparation of an artificial kidney perfusion fluid for bicarbonate dialysis and a method of producing the same.A granular to fine-granular Composition A comprising granules each comprised of a plurality of NaCl grains carrying KCl, CaCl.sub.2, MgCl.sub.2 and sodium acetate adhered to the surface of each grain.NaCl, KCl CaCl.sub.2, MgCl.sub.2 and sodium acetate are mixed in the presence of not less than 10 weight parts of water based on 100 weight parts of sodium acetate and the resultant mixture is heated at not less than 50.degree. C. to bring the sodium acetate into a transiently molten state and mixing acetic acid with the same mixture.Type: GrantFiled: December 13, 1993Date of Patent: July 30, 1996Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Hideyuki Aoyama, Hisao Mukai, Kazuya Murakami
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Patent number: 5169825Abstract: The present invention provides an ammonium ion- and ammonia-selective adsorbent.According to the invention, an ammonium ion-selective adsorbent can be obtained by introducing alkali metal ions capable of ion exchange into a silica-alumina composite oxide having a specific composition, the obtained adsorbent being capable of selectively adsorbing ammonium ions and ammoniacal nitrogen without affecting other components in seawater as well as fresh water, and being capable of keeping the pH value of seawater varied within an extremely narrow range.The adsorbent of the invention is also useful as an adsorbent for adsorption of ammonia gas.Type: GrantFiled: October 28, 1991Date of Patent: December 8, 1992Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Akira Okubo, Toshihiro Kamewa, Hironobu Hayashi, Keiko Miyawaki
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Patent number: 5073385Abstract: Discosed are (i) a boehmite-type aluminum hydroxide which is represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1; and (ii) a process for preparing a boehmite-type aluminum hydroxide represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1, the process comprising surface-treating a boehmite-type aluminum hydroxide with sulfuric acid or a sulfate capable of forming sulfuric acid by heating or by hydrolysis, the boehmite-type aluminum hydroxide to be treated being represented by the formulaAlO(OH).mH.sub.2 Owherein 0.ltoreq.m<1.Type: GrantFiled: November 13, 1989Date of Patent: December 17, 1991Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Takeshi Suzuki, Mineaki Kabayama
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Patent number: 5045324Abstract: The invention provides a pasty composition for perfusing artificial kidney systems for dialysis, the composition comprising about 30 to about 70% by weight of solid electrolyte components consisting of NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa and about 70 to about 30% by weight of water, and the composition having a viscosity of about 1,000 to about 7,000 cps at 25.degree. C., and also provides a process for preparing a pasty composition for perfusing artificial kidney systems for dialysis, the process comprising the steps of uniformly mixing NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa, adding water and finely dividing the mixture.Type: GrantFiled: November 27, 1989Date of Patent: September 3, 1991Assignee: Tomita Pharmaceutical Co., Ltd.Inventor: Hisao Mukai
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Patent number: 4931289Abstract: An oral phosphate ion-adsorbing agent containing as an effective component a boehmite-type aluminum hydroxide which is represented by the formulaAlO(OH).multidot.nH.sub.2 Owherein 0.ltoreq.n<1 and which is about 0.2 to about 1.0 meq/g in the amount of active OH group present on the surface thereof and at least about 200 m.sup.2 /g in the BET specific surface area.Type: GrantFiled: November 15, 1988Date of Patent: June 5, 1990Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Takeshi Suzuki, Mineaki Kabayama