Patents Assigned to Tomita Pharmaceuticals Co., Ltd.
  • Publication number: 20130059151
    Abstract: Provided is a magnesium oxide for pharmaceutical use that, when mixed with a drug that is unstable in acid, demonstrates high stabilizing effects on the drug while also demonstrating superior stability of the magnesium oxide per se. The magnesium oxide for pharmaceutical use is used by being mixed with a drug that is unstable in acid, and has a specific surface area as determined according to the BET method of 20 m2/g to 200 m2/g and a degree of activation of 40 Img/g to 200 Img/g.
    Type: Application
    Filed: October 20, 2011
    Publication date: March 7, 2013
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto
  • Patent number: 8186415
    Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: May 29, 2012
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
  • Publication number: 20120018915
    Abstract: The present invention provides a powder for molding that reduces or prevents drawbacks such as unevenness and low fluidity when a mixed powder is used as a powder for molding. The present invention relates to powders for molding including particles in which each particle contains an inorganic component and a water-soluble organic polymer component and methods for producing the same.
    Type: Application
    Filed: February 26, 2010
    Publication date: January 26, 2012
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Akira Ookubo, Tomohide Koizumi, Kazuma Tamura
  • Publication number: 20110186257
    Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.
    Type: Application
    Filed: April 8, 2011
    Publication date: August 4, 2011
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
  • Patent number: 7942187
    Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: May 17, 2011
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
  • Publication number: 20110059247
    Abstract: [Object] To form a modeled object with high accuracy. [Solving Means] A powder transfer mechanism (16) laminates powder layers containing water-soluble powder as a main component one by one at a modeling portion (14). An inkjet line head (17) injects a water-based ink that dissolves the powder in an area of an uppermost layer of the powder layers laminated by the powder transfer mechanism (16), the area corresponding to a cross-sectional shape of a modeled object. Then, a heater (18) heats the powder for each layer of the powder layers. Further, the heater (18) heats the powder after the water-based ink is injected by the inkjet line head (17) or before the water-based ink is injected by the inkjet line head (17). The present invention can be applied to a modeling apparatus, for example.
    Type: Application
    Filed: May 14, 2009
    Publication date: March 10, 2011
    Applicants: Sony Corporation, Tomita Pharmaceutical Co., Ltd.
    Inventors: Junichi Kuzusako, Masanobu Yamamoto, Akira Ookubo, Toshihiro Kamewa, Tomohide Koizumi, Kazuma Tamura, Takeshi Matsui
  • Publication number: 20100260856
    Abstract: The present invention provides a core particle for a pharmaceutical preparation which features the requisite properties of a core particle, and which has enough chemical stability, and in which reactivity with the drug (an active pharmaceutical ingredient) is limited or prevented. More specifically, the present invention relates to a core particle wherein a film containing an active pharmaceutical ingredient can be formed on the surface thereof, and (1) the core particle comprises a pharmaceutically acceptable inorganic material, (2) the inorganic material is poorly soluble in water, and (3) pH of a solution of the inorganic material is 5 to 8.
    Type: Application
    Filed: September 8, 2008
    Publication date: October 14, 2010
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Masashi Konishi, Shouichi Oonishi, Akira Ookubo, Masashi Yunoki, Ariumi Kawamoto, Kanako Hattori
  • Publication number: 20090008055
    Abstract: A method for manufacturing a mold, including steps of (a) expanding a powder mixture containing a water-soluble inorganic salt powder and a water-soluble organic polymer powder in a plane on a table and then selectively spraying a spray liquid containing at least one selected from a water-miscible organic solvent and water through a nozzle on this powder mixture layer to make a bonding strength among particles of the powder mixture in a sprayed region higher than that among particles of the powder mixture in an unsprayed region, (b) further expanding the powder mixture on the powder mixture layer after spraying and then selectively spraying the spray liquid through the nozzle on this powder mixture layer, (c) repeatedly conducting the step (b) over several times to form a mold shaped by the sprayed regions, and (d) taking out the mold.
    Type: Application
    Filed: December 19, 2006
    Publication date: January 8, 2009
    Applicant: TOMITA PHARMACEUTICAL CO., LTD.
    Inventors: Yoji Marutani, Minoru Tomita, Hisaaki Hashimoto, Tomohide Koizumi, Kazuhiko Tamagawa, Akira Ookubo, Nozomu Hashimoto
  • Patent number: 7473300
    Abstract: A moisture absorbent composition is provided with a thermoplastic resin; and a moisture absorbent kneaded into the thermoplastic resin, having a secondary particle size of substantially 1 to 40 ?m, wherein equilibrium humidity is controlled by selecting the specific gravity of the thermoplastic resin. A method for controlling equilibrium humidity in a moisture absorbent composition obtained by kneading a moisture absorbent into a thermoplastic resin is provided, which includes kneading the moisture absorbent such that a secondary particle size of the moisture absorbent is substantially 1 to 40 ?m; and controlling equilibrium humidity by selecting specific gravity of the thermoplastic resin.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: January 6, 2009
    Assignees: Sasaki Chemicals Co., Ltd., Tomita Pharmaceutical Co., Ltd.
    Inventors: Katsuhiko Uegaki, Toru Sakiyama
  • Publication number: 20010019727
    Abstract: A biocidal material comprising, as an active ingredient, a compound represented by General Formula (1)
    Type: Application
    Filed: December 13, 2000
    Publication date: September 6, 2001
    Applicant: Secretary, Agency of Industrial Science and Technology & Tomita Pharmaceutical Co., Ltd.
    Inventors: Yoji Makita, Osamu Ikai, Kenta Ooi, Akinari Sonoda, Masahito Taya, Motomu Nishioka, Akira Ookubo, Mikiko Mihara
  • Patent number: 6132624
    Abstract: A method for treating phosphate-containing waste water comprising treating phosphate-containing waste water with a metal hydroxide complex as a phosphate adsorbent represented by formula (1):M.sub.1-x.sup.2+ M.sub.x.sup.3+ (OH.sup.-).sub.2+x-y (A.sup.n-).sub.y/n(1)wherein M.sup.2+ represents at least one divalent metal ion selected from the group consisting of Mg.sup.2+, Ni.sup.2+, Zn.sup.2+, Fe.sup.2+, Ca.sup.2+ and Cu.sup.2+, M.sup.3+ represents at least one trivalent metal ion selected from the group consisting of Al.sup.3+ and Fe.sup.3+, A.sup.n- represents n-valent anion, 0.1.ltoreq.x.ltoreq.0.5, 0.1.ltoreq.y.ltoreq.0.5 and n is 1 or 2 to adsorb phosphate is provided.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: October 17, 2000
    Assignee: Tomita Pharmaceutical Co. LTD
    Inventors: Takashi Suzuki, Toshio Sato, Akira Ookubo, Tomohide Koizumi, Mikiko Mihara, Shouichi Oonishi
  • Patent number: 6013238
    Abstract: This invention aims to provide titanate whiskers which are excellent in heat resistance, chemical resistance and reinforcing effect and are low in coefficient of thermal conductivity.The titanate whiskers of the invention are those represented by the formulaA.sup.I.sub.v A.sup.II.sub.w M.sup.II.sub.x M.sup.III.sub.y Ti.sub.8-z O.sub.16wherein A.sup.I is at least one member selected from alkali metals, A.sup.II is Ba, M.sup.II is at least one member selected from the group consisting of Mg, Co, Ni, Zn, Cu and Mn, M.sup.III is at least one member selected from the group consisting of Al, Sc, Cr, Fe and Ga, and v, w, x, y and z are real numbers which fulfill 0.5.ltoreq.2x+y.ltoreq.2.5, 2x+y=v+2w, and z=x+y.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: January 11, 2000
    Assignees: Otsuka Kagaku Kabushiki Kaisha, Tomita Pharmaceutical Co., Ltd.
    Inventors: Hiroki Murata, Masayoshi Suzue, Akiyoshi Kawaguchi, Fauzi Faustinus, Toshihiro Kamewa, Tomohide Koizumi
  • Patent number: 5976401
    Abstract: A method for treating phosphate-containing waste water comprising treating phosphate-containing waste water with a metal hydroxide complex as a phosphate adsorbent represented by the formula:M.sub.1-x.sup.2+ M.sub.x.sup.3+ (OH.sup.-).sub.2+x-y (A.sup.n-).sub.y/nwherein M.sup.2+ is at least one divalent metal ion selected from the group consisting of Mg.sup.2+, Ni.sup.2+, Zn.sup.2+, Fe.sup.2+, Ca.sup.2+ and Cu.sup.2+ ; M.sup.3+ is at least one divalent metal ion selected from the group consisting of Al.sup.3+ and Fe.sup.3+ ; A.sup.n- is an n-valent anion; x is in the range 0.1.ltoreq.x.ltoreq.0.5; y is in the range 0.1.ltoreq.y.ltoreq.0.5; and n is 1 or 2.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: November 2, 1999
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Takashi Suzuki, Toshio Sato, Akira Ookubo, Tomohide Koizumi, Mikiko Mihara, Shoichi Oonishi
  • Patent number: 5942205
    Abstract: This invention aims to provide titanate whiskers which are excellent in heat resistance, chemical resistance and reinforcing effect and are low in coefficient of thermal conductivity.The titanate whiskers of the invention are those represented by the formulaA.sup.I.sub.v A.sup.II.sub.w M.sup.II.sub.x M.sup.III.sub.y Ti.sub.8-z O.sub.16wherein A.sup.I is at least one member selected from alkali metals, A.sup.II is Ba, M.sup.II is at least one member selected from the group consisting of Mg, Co, Ni, Zn, Cu and Mn, M.sup.III is at least one member selected from the group consisting of Al, Sc, Cr, Fe and Ga, and v, w, x, y and z are real numbers which fulfill 0.5.ltoreq.2x+y.ltoreq.2.5, 2x+y=v+2w, and z=x+y.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: August 24, 1999
    Assignees: Otsuka Kagaku Kabushiki Kaisha, Tomita Pharmaceutical Co., Ltd.
    Inventors: Hiroki Murata, Masayoshi Suzue, Akiyoshi Kawaguchi, Fauzi Faustinus, Toshihiro Kamewa, Tomohide Koizumi
  • Patent number: 5674715
    Abstract: A method for producing uridine diphosphate N-acetylglucosamine comprising culturing osmo-tolerant yeasts in aerobic conditions in a medium having inorganic salt concentration of about 2-8%.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: October 7, 1997
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Minoru Tomita, Hisao Mukai
  • Patent number: 5540842
    Abstract: A granular to fine-granular dry mix powder (an artificial kidney perfusion component A of uniform composition) for use in the preparation of an artificial kidney perfusion fluid for bicarbonate dialysis and a method of producing the same.A granular to fine-granular Composition A comprising granules each comprised of a plurality of NaCl grains carrying KCl, CaCl.sub.2, MgCl.sub.2 and sodium acetate adhered to the surface of each grain.NaCl, KCl CaCl.sub.2, MgCl.sub.2 and sodium acetate are mixed in the presence of not less than 10 weight parts of water based on 100 weight parts of sodium acetate and the resultant mixture is heated at not less than 50.degree. C. to bring the sodium acetate into a transiently molten state and mixing acetic acid with the same mixture.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: July 30, 1996
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Hideyuki Aoyama, Hisao Mukai, Kazuya Murakami
  • Patent number: 5169825
    Abstract: The present invention provides an ammonium ion- and ammonia-selective adsorbent.According to the invention, an ammonium ion-selective adsorbent can be obtained by introducing alkali metal ions capable of ion exchange into a silica-alumina composite oxide having a specific composition, the obtained adsorbent being capable of selectively adsorbing ammonium ions and ammoniacal nitrogen without affecting other components in seawater as well as fresh water, and being capable of keeping the pH value of seawater varied within an extremely narrow range.The adsorbent of the invention is also useful as an adsorbent for adsorption of ammonia gas.
    Type: Grant
    Filed: October 28, 1991
    Date of Patent: December 8, 1992
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Akira Okubo, Toshihiro Kamewa, Hironobu Hayashi, Keiko Miyawaki
  • Patent number: 5073385
    Abstract: Discosed are (i) a boehmite-type aluminum hydroxide which is represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1; and (ii) a process for preparing a boehmite-type aluminum hydroxide represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1, the process comprising surface-treating a boehmite-type aluminum hydroxide with sulfuric acid or a sulfate capable of forming sulfuric acid by heating or by hydrolysis, the boehmite-type aluminum hydroxide to be treated being represented by the formulaAlO(OH).mH.sub.2 Owherein 0.ltoreq.m<1.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: December 17, 1991
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Takeshi Suzuki, Mineaki Kabayama
  • Patent number: 5045324
    Abstract: The invention provides a pasty composition for perfusing artificial kidney systems for dialysis, the composition comprising about 30 to about 70% by weight of solid electrolyte components consisting of NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa and about 70 to about 30% by weight of water, and the composition having a viscosity of about 1,000 to about 7,000 cps at 25.degree. C., and also provides a process for preparing a pasty composition for perfusing artificial kidney systems for dialysis, the process comprising the steps of uniformly mixing NaCl, KCl, CaCl.sub.2, MgCl.sub.2 and CH.sub.3 COONa, adding water and finely dividing the mixture.
    Type: Grant
    Filed: November 27, 1989
    Date of Patent: September 3, 1991
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventor: Hisao Mukai
  • Patent number: 4931289
    Abstract: An oral phosphate ion-adsorbing agent containing as an effective component a boehmite-type aluminum hydroxide which is represented by the formulaAlO(OH).multidot.nH.sub.2 Owherein 0.ltoreq.n<1 and which is about 0.2 to about 1.0 meq/g in the amount of active OH group present on the surface thereof and at least about 200 m.sup.2 /g in the BET specific surface area.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: June 5, 1990
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Takeshi Suzuki, Mineaki Kabayama