Patents Assigned to Tomo Nishimoto
  • Method for detecting candidate alzheimer's disease drug
    Patent number: 8252543
    Abstract: The present invention provides a method for detecting or diagnosing in vitro Alzheimer's disease, or memory and/or cognitive disorders, using a human biological sample and the inactivation of STAT3 protein as an indication, and a method for screening for a therapeutic drug for Alzheimer's disease or memory and/or cognitive disorders, using the activation of STAT3 protein as an indication.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: August 28, 2012
    Assignees: Tomohiro Chiba, Marina Yamada, Kenzo Terashita, Tomo Nishimoto, Sadakazu Aiso, Masaaki Matsuoka
    Inventors: Tomohiro Chiba, Marina Yamada, Kenzo Terashita, Sadakazu Aiso, Masaaki Matsuoka
  • Therapeutic agents of colivelin for neurodegenerative diseases
    Patent number: 8076449
    Abstract: The present invention relates to a pharmaceutical composition for the treatment and/or prevention of a neurodegenerative disease, comprising the following polypeptide shown in any of (a) to (c): (a) a polypeptide comprising the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1); (b) a polypeptide comprising an amino acid sequence having a deletion, substitution, insertion, and/or addition of one or several amino acids in the amino acid sequence consisting of Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death associated with neurodegenerative disease; and (c) a modified polypeptide from the polypeptide (a) or (b), or a pharmaceutically acceptable salt thereof, as an effective ingredient.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: December 13, 2011
    Assignees: Tomohiro Chiba, Massaaki Matsuoka, Kenzo Terashita, Sadakazu Also, Tomo Nishimoto
    Inventors: Tomohiro Chiba, Yoshiko Kita, Masaaki Matsuoka, Kenzo Terashita, Sadakazu Aiso, Ikuo Nishimoto, Tomo Nishimoto, legal representative
  • Method for detecting Alzheimer's disease
    Publication number: 20080102055
    Abstract: The present invention provides a method for detecting or diagnosing in vitro Alzheimer's disease, or memory and/or cognitive disorders, using a human biological sample and the inactivation of STAT3 protein as an indication, and a method for screening for a therapeutic drug for Alzheimer's disease or memory and/or cognitive disorders, using the activation of STAT3 protein as an indication.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 1, 2008
    Applicants: Tomohiro CHIBA, Marina YAMADA, Kenzo TERASHITA, Tomo NISHIMOTO, Sadakazu AISO, Masaaki MATSUOKA
    Inventors: Tomohiro Chiba, Marina Yamada, Kenzo Terashita, Sadakazu Aiso, Masaaki Matsuoka