Abstract: In a machine for filling and closing tubes, an endless conveying line has equispaced gripping members for loading tubes with vertical axis and with open bottoms turned upwards. The line is operated stepwise for transferring the tubes, one by one, to subsequent stations arranged along the line for carrying out operations of cleaning inside the tubes, orienting outer prints, filling the tubes with measured quantities of product, closing the bottoms, applying codes, and possibly trimming the tubes. The machine includes also a station for expulsion of rejected tubes and a download station for transferring good tubes to an outlet line. Configuration of the line and arrangement of the stations are designed to reduce dimensions, simplify construction and limit costs of the machine, at the same time ensuring high reliability.