Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
Type:
Grant
Filed:
August 30, 2013
Date of Patent:
October 27, 2015
Assignees:
MERIAL, INC., Top Industrie S.A.S.
Inventors:
Nicolas Pierre Yves Carboulec, Gildas Merian, Rene Labatut, Lionel Gerentes
Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
Type:
Application
Filed:
August 30, 2013
Publication date:
March 6, 2014
Applicants:
TOP INDUSTRIE S.A.S., MERIAL LIMITED
Inventors:
Nicolas Pierre Yves Carboulec, Gildas Merian, Rene Labatut, Lionel Gerentes