Abstract: A rim drilling and milling machine has a base (10), a column (20), a turret (30), a saddle (40), a table (50), and a fixture unit (60). The fixture unit (60) has a foundation (61) and four clamping seats defined as two first clamping seats (63A) and two second clamping seats (63B). The first clamping seats (63A) are slidably mounted on the foundation (61) along a first radial direction, and are disposed at positions diametrically opposite in the first radial direction. The second clamping seats (63B) are slidably mounted on the foundation (61) along a second radial direction perpendicular to the first radial direction, and are disposed at positions diametrically opposite in the second radial direction. The four clamping seats can clamp at four equiangular points of a wheel rim.