Abstract: The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
Type:
Grant
Filed:
May 24, 2018
Date of Patent:
January 26, 2021
Assignee:
Topas Therapeutics GmbH
Inventors:
Barbara Freund, Jörg Heeren, Peter Nielsen, Antonella Carambia, Johannes Herkel, Oliver Bruns, Ansgar Lohse, Stefan Lüth, Horst Weller, Sunhild Salmen
Abstract: The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
Type:
Grant
Filed:
November 14, 2012
Date of Patent:
June 26, 2018
Assignee:
TOPAS THERAPEUTICS GmbH
Inventors:
Barbara Freund, Jörg Heeren, Peter Nielsen, Antonella Carambia, Johannes Herkel, Oliver Bruns, Ansgar Lohse, Stefan Lüth, Horst Weller, Sunhild Salmen