Abstract: A safe and quick release device for a tool adapter includes a main body and a combination head. The main body has its front end axially bored with a combination groove with an open end. The combination groove has its opposite sides respectively bored with at least one position-limiting hole having its opposite ends respectively and annularly formed with a first position-limiting portion and a second position-limiting portion. A spherical position-limiting member is slidably disposed in the position-limiting hole and restrictedly positioned therein by the first and the second position-limiting portion. Thus, the position-limiting member is ready made, needless to be especially processed, can easily be in stalled for facilitating assembly and disassembly of the combination head, reducing processing cost.