Abstract: A method for performing reconstruction for a region of interest (ROI) of an object is provided. The method includes designating the ROI within the object, the ROI being located within a scan field of view (FOV) of a combined third- and fourth-generation CT scanner, the CT scanner including fixed photon-counting detectors (PCDs), and an X-ray source that rotates about the object in synchronization with a rotating detector. Further, the method includes determining, for each PCD, as a function of view angle, an on/off timing schedule, based on a size and location of the designated ROI, and performing a scan to obtain a first data set from the rotating detector and a second data set from the plurality of PCDs, while turning each PCD on and off according to the determined schedule. Finally, the method includes performing reconstruction using the first and second data sets to obtain ROI spectral images.