Abstract: The present disclosure provides mutant vaccinia virus strains that can selectively replicate in tumor cells. The present disclosure also provides use of the mutant vaccinia virus strains for preventing and treating tumors.
Abstract: The present disclosure provides tumor vaccines useful for preventing and treating tumors and cancers. The tumor vaccines may contain nucleic acids encoding for antigen presenting peptides, cytokines and other factors useful for preventing and treating tumors and cancers, or expression vectors or viruses containing such nucleic acids, or host cells containing such nucleic acids or expression vectors.