Abstract: Disclosed are cleaning devices and methods of use thereof for cleaning a vertical stack plumbing system. The cleaning device includes a first cylindrical body defining a first opening for selectively introducing a predetermined amount of cleaning medium into the cleaning device; a second cylindrical body defining a second opening configured to maintain airflow and venting of the vertical stack plumbing system when the cleaning device is in use, the first and second cylindrical bodies being directly connected to a main body of the cleaning device and in fluid communication with one another through the main body; and an attachment member defining a third opening that is directly connected to the main body of the cleaning device, the attachment member configured for direct removable attachment to a plumbing waste pipe in the vertical stack plumbing system and for receiving the cleaning medium therethrough to introduce the cleaning medium into the vertical stack plumbing system.