Patents Assigned to Total Synthesis, Ltd.
  • Patent number: 11680955
    Abstract: A fluid diverting module includes a multi-position fluid diverting device comprising three-dimensional movable flow-paths with minimal tortuosity in the movable portion (the rotor) of the fluid diverting device. In some embodiments, the device is also equipped with a filtration module that is capable of filtering solid particulates from fluidic samples. The invention relates to an area of non-disruptive sampling from various sample sources including ones containing solids. The fluid diverting device maintains fluid communication between the sample source and a pressure creating device in all positions of the fluid diverting device, thus conserving the pressure inside the sample source during sampling. The sampling operation is controlled from a controller, which is equipped with a software for manual or intelligent control.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 20, 2023
    Assignee: Total Synthesis Ltd.
    Inventors: Michael Organ, Debasis Mallik, Wenyao Zhang
  • Patent number: 9579625
    Abstract: A fluid processing assembly includes a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: February 28, 2017
    Assignee: Total Synthesis Ltd.
    Inventors: Michael Organ, Debasis Mallik
  • Publication number: 20140087036
    Abstract: A fluid processing assembly comprises a lumen for receiving at least one inlet stream and dispensing a primary product stream, and an energizing device for supplying energy to an energizable portion of the lumen. A primary product collection assembly is in fluid communication with the lumen for receiving the primary product stream. The energizable portion is positioned exterior to the primary product collection assembly. A pressurized gas source is downstream of the lumen. The pressurized gas source supplies pressurized gas to the primary product collection assembly for pressurizing at least a portion of the primary product collection assembly and the lumen.
    Type: Application
    Filed: September 20, 2013
    Publication date: March 27, 2014
    Applicant: TOTAL SYNTHESIS LTD.
    Inventors: Michael ORGAN, Debasis MALLIK
  • Publication number: 20070212267
    Abstract: A reactor apparatus includes at least one reaction capillary having a lumen for receiving a reactant to undergo a reaction, and a magnetron for irradiating reactant contained in at least a portion of the capillary with microwaves. A method of micro-reacting a reactant includes providing a capillary, and irradiating the reactant in the capillary with microwaves to facilitate a chemical reaction in the capillary by which the reactant is converted into a desired product.
    Type: Application
    Filed: February 28, 2007
    Publication date: September 13, 2007
    Applicant: Total Synthesis Ltd.
    Inventors: Michael Organ, Eamon Comer
  • Patent number: 7250510
    Abstract: The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 31, 2007
    Assignee: Total Synthesis, Ltd.
    Inventors: Michael G. Organ, Christopher J. O'Brien, Assam (Eric) B. Kantchev
  • Publication number: 20070073055
    Abstract: The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.
    Type: Application
    Filed: August 23, 2006
    Publication date: March 29, 2007
    Applicant: Total Synthesis, Ltd.
    Inventors: Michael Organ, Christopher O'Brien, Assam (Eric) Kantchev