Abstract: A method and system for designing an integrated circuit layout are disclosed. In one embodiment, the method includes generating a stem cell library with stem cell layouts, wherein each stem cell layout includes an analog core area where a device element resides, and abutment boundaries on left, right, top, and bottom sides of the analog core area. The method also includes mapping device elements in a schematic netlist to the stem cell layouts in the stem cell library. In addition, the method includes placing and routing the mapped device elements to optimize a layout for the schematic netlist.