Abstract: The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates (ADCs) comprising the novel anthracycline derivatives and the use of such ADCs in the prevention and treatment of cancer are disclosed.
Type:
Grant
Filed:
May 30, 2017
Date of Patent:
June 2, 2020
Assignee:
Toxinvent Ou
Inventors:
Ain Uustare, Ivan Ogibalov, Olga T{hacek over (s)}ubrik, Andrus Tasa, Uno Mäeorg, Ago Rinken