Patents Assigned to Toyama Chemical Company Limited
  • 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition salts thereof and process for producing same
    Patent number: 4460774
    Abstract: A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.
    Type: Grant
    Filed: February 12, 1982
    Date of Patent: July 17, 1984
    Assignee: Toyama Chemical Company, Limited
    Inventors: Takako Hori, Chosaku Yoshida, Yasuo Kiba, Ryuko Takeno, Joji Nakano, Jun Nitta, Sumiko Kishimoto, Shohachi Murakami, Hisatsugu Tsuda, Isamu Saikawa
  • Intermediate for cephalosporin type compound
    Patent number: 4237280
    Abstract: The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.
    Type: Grant
    Filed: September 25, 1978
    Date of Patent: December 2, 1980
    Assignee: Toyama Chemical Company, Limited
    Inventors: Isamu Saikawa, Shuntaro Takano, Kaishu Momonoi, Isamu Takakura, Chiaki Kutani, Kiyoshi Tanaka, Kenshin Hayashi
  • Novel penicillins and cephalosporins and process for producing same
    Patent number: 4219554
    Abstract: Novel penicillins and non-toxic salts thereof, which contain a mono- or di-oxo- or thioxo-piperazino(thio)carbonylamino group have been prepared. These compounds are valuable antibacterial compounds for use in mammals including man. A process for the preparation of the compounds has also been discovered.
    Type: Grant
    Filed: June 15, 1978
    Date of Patent: August 26, 1980
    Assignee: Toyama Chemical Company, Limited
    Inventors: Isamu Saikawa, Shuntaro Takano, Chosaku Yoshida, Okuta Takashima, Kaishu Momonoi, Seietsu Kuroda, Miwako Komatsu, Takashi Yasuda, Yutaka Kodama
  • Substituted 7.alpha.-methoxy-7.beta.[(2,3-dioxo-1-piperazinyl)carbonylaminophenylace tamido]cephalosporins
    Patent number: 4200744
    Abstract: Novel 7.alpha.-methoxy-cephalosporins and non-toxic salts thereof, which contain a di-oxo-piperazinyl-carbonylamino group in molecule. These compounds are valuable antibacterial compounds for use in mammals including man. This disclosure relates to such compounds and methods for producing the same.
    Type: Grant
    Filed: October 27, 1977
    Date of Patent: April 29, 1980
    Assignee: Toyama Chemical Company, Limited
    Inventors: Isamu Saikawa, Shuntaro Takano, Hiroyuki Imaizumi, Isamu Takakura, Hirokazu Ochiai, Takashi Yasuda, Hideo Taki, Masuru Tai, Yutaka Kodama
  • Antibacterial composition for medical use
    Patent number: 4199566
    Abstract: An antibacterial composition for medical use comprising 6-[-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino)phenylacetamid o]penicillanic acid or a pharmaceutically acceptable salt thereof and a .beta.-lactamase-inhibiting penicillin or cephalosporin. The composition exhibits synergistic effect which is much greater than the sum of antibacterial effects of each component used alone.
    Type: Grant
    Filed: June 6, 1978
    Date of Patent: April 22, 1980
    Assignee: Toyama Chemical Company, Limited
    Inventors: Isamu Saikawa, Takashi Yasuda, Masaru Tai, Yutaka Takashita, Hiroshi Sakai, Michiko Mae, Masahiro Takahata, Susumu Mitsuhashi
  • Alkanoic acid, process for its production and method of use thereof
    Patent number: 4092350
    Abstract: A novel 2-[4-(3-oxo- or hydroxy-alkyl)phenyl]alkanoic acid and a non-toxic salt thereof. These compounds are useful for treating symptoms of inflammation and pain in mammals including man. This disclosure relates to such compounds, a process for producing the same, a pharmaceutical composition containing such a compound, and a method for treating symptoms of inflammation and pain.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: May 30, 1978
    Assignee: Toyama Chemical Company Limited
    Inventors: Koji Miura, Kenjun Takeshima, Takuya Kodama, Masashi Imamura, Kyoko Hongo, Noboru Takagawa, Yukitaka Hamatani, Yasuyuki Suzuki