Abstract: A polyfunctional disulfide compound, useful as a cross-linking reagent having S--S exchange reactivity, of the formula ##STR1## wherein R is 2-benzothiazolyl or 2-pyridyl-N-oxide and X is a spacer group having an alkylene group directly bonded to each S--S group.

Abstract: L-.alpha.-glycerophosphate oxidase can be produced by culturing Aerococcus viridans IFO-12219 or Aerococcus viridans IFO-12317. It is useful for analysis for L-.alpha.-glycerophosphate, because it catalyzes the reaction of L-.alpha.-glycerophosphate and oxygen to form dihydroxyacetone phosphate and hydrogen peroxide.

Abstract: Derivatives of antibiotic tylosin of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkanoyl, A.sub.1 and A.sub.2 are groups of which one is R.sub.2 and the other is R.sub.3, and R.sub.2 and R.sub.3 are C.sub.2-6 alkanoyl, or a physiologically acceptable salt thereof, have enhanced antibacterial activity against macrolide antibiotic-resistant strains.

Abstract: A disulfide derivative, having S--S exchange reactivity, of the formulaR.sub.1 --S--S--R.sub.2 --CO--R.sub.3).sub.n R.sub.4 [I]wherein R.sub.1 is 2-benzothiazolyl or 2-pyridyl-N-oxide, R.sub.2 is alkylene having optionally free or protected functional groups, R.sub.3 is the carboxyl residue of an amino acid or lower polypeptide, R.sub.4 is carboxyl or a reactive derivative thereof or protected carboxyl or imidate, and n is 0 or 1.

Abstract: Pyruvate oxidase can be produced by culturing Pediococcus sp. B-0667, Streptococcus sp. B-0668, Aerococcus viridans IFO-12219 or Aerococcus viridans IFO-12317. It is useful for analysis for pyruvic acid, because it catalyzes the reaction of pyruvic acid, phosphate and oxygen to form acetylphosphate, carbon dioxide and hydrogen peroxide. A kit containing the various reagents for such analysis is also provided by this invention.

Abstract: 3"-acylated macrolide antibiotics of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.2-3 alkanoyl, R.sub.2 is hydrogen or C.sub.2-4 alkanoyl, at least one of R.sub.1 and R.sub.2 being hydrogen, and one of R' and R" being R.sub.3 and the other R.sub.4, R.sub.3 being C.sub.2-6 alkanoyl and R.sub.4 being C.sub.2-5 alkanoyl, or a pharmaceutically acceptable salt thereof.

Abstract: A disulfide compound of a carrier, having S--S exchange reactivity, of the formulaR--S--S--X.sub.1 --X.sub.2 --A [I]wherein R is 2-benzothiazolyl, X.sub.1 is a spacer group directly bound to the --S--S-- and comprises a plurality of carbon atoms in a straight or branched chain, X.sub.2 is an imide or amide bonding group, and A is an insoluble carrier selected from the group consisting of beads gel agarose residue, gamma-aminopropylated nylon beads residue and a residual group of partially reduced polyacrylonitrile porous granules or fibers.

Abstract: Novel enzyme lactate oxidase can be produced by culturing Pediococcus sp. B-0667, Streptococcus sp. B-0668, Aerococcus viridans IFO-12219 or Aerococcus viridans IFO-12317. It is useful for analysis for L-lactic acid, because it catalyzes the reaction of L-lactic acid and oxygen to form pyruvic acid and hydrogen peroxide. A kit containing the various reagents for such analysis is also provided by this invention.

Abstract: An enzyme sarcosine oxidase is produced by culturing a microorganism belonging to the genus Bacillus, and particularly the species Bacillus sp. B-0618, FERM-P No. 4049, NRRL No. B-11380, and isolating the sarcosine oxidase thus produced from the culture medium. Sarcosine oxidase is useful for the determination of creatinine in the presence of creatinase and creatininase in a sample by mixing the enzymes with the sample and then measuring the generated hydrogen peroxide, formaldehyde or glycine.

Abstract: Antibiotics aculeacin-A.alpha., -A.gamma., -D.alpha. and -D.gamma. are active against yeasts and fungi. They are produced by culturing the microorganism Aspergillus aculeatus NRRL 11270 in a nutrient medium containing assimilable carbon and nitrogen sources.

Abstract: A novel enzyme choline oxidase is produced by culturing a microorganism belonging to the genus Arthrobacter, and particularly the species Arthrobacter globiformis B-0577 FERM-P No. 3518, NRRL B-11097, and isolating the choline oxidase thus produced from the culture medium. Choline oxidase is useful for the determination of choline or betaine aldehyde in a sample by mixing the new product with the sample and then measuring the generated hydrogen peroxide, betaine or consumed oxygen.

Abstract: Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr or Phe, A.sub.23 is Arg or Gln, A.sub.25 is Asp or Asn or Ala, A.sub.26 is Val or Thr or Ile, A.sub.28 is Ala or Ser or Val, and A.sub.30 is Thr or Val or Ala, and pharmaceutically acceptable acid addition salts and complexes, have serum calcium reducing activity.

Abstract: The invention relates to a group of novel N,N'-di-substituted amines, especially adapted for use as antitussive agent.These compounds can be expressed by the following general formula: ##SPC1##WhereinR.sub.1 stands for a member selected from the group consisting of hydrogen, methyl and methoxy;R.sub.2 stands for a member selected from the group consisting of phenyl, tolyl, xylyl, ethylphenyl, o- and m-methoxyphenyl, trimethylphenyl and .alpha. -naphthyl.

Abstract: A polypeptide having calcitonin activity of the formula ##EQU1## and the salts thereof with pharmaceutically acceptable acids.

Abstract: A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.

Abstract: 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.

Abstract: Novel diacyl penicillins of the formula ##EQU1## wherein R is alkyl, cycloalkyl, aryl, aralkyl, phenoxyalkyl, heterocyclic carboxyl excepting isoxazole carboxyl derivatives, or ##SPC1##In which benzene ring A may optionally be substituted andB represents a protective group for the amino group, and X is a protective group for the carboxyl group, are produced by reacting a benzyl penicillin ester of the formula ##EQU2## wherein X is as defined above, with a chlorinating agent in the presence of tertiary organic base to obtain an imide chloride group-incorporated compound of the formula ##EQU3## and then reacting the compound of the last-named formula with carboxylate of the formulaR-COOM (IV)wherein M is a metal atom, and R is as defined above.