Abstract: The present invention provides markers of endothelial progenitor cells (EPCs) and use of those markers and reagents that bind thereto to detect EPC cells or diagnose, prognose, treat or prevent EPC-associated conditions.
Type:
Application
Filed:
November 7, 2011
Publication date:
August 29, 2013
Applicant:
TransBio Ltd.
Inventors:
Claudine Sharon Bonder, Angel Fransciso Lopez, Gert Hoy Talbo
Abstract: The present disclosure provides an isolated protein comprising at least one antibody variable region that is capable of binding to peptidase inhibitor 16 (PI16), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16. The present invention also provides use of the protein, e.g., in diagnosis, therapy or to isolate cells, preferably Treg cells.
Type:
Application
Filed:
April 18, 2011
Publication date:
July 4, 2013
Applicant:
TransBio Ltd.
Inventors:
Simon Barry, Doreen Krumbiegel, Nicola Ga-Ling Eastaff-Leung, Ian Cameron Nicholson, Heddy Zola