Patents Assigned to Transcell Technologies, Inc.
  • Process for preparing sulfoxides
    Patent number: 5731423
    Abstract: A process is disclosed for making a compound having a sulfoxide group comprising providing a first compound having a sulfide group and contacting said first compound with an oxidizing agent in the presence of silica and a carboxylic acid anhydride. In a particular embodiment of the invention, the high yield preparation of glycoside moieties having anomeric sulfoxides at ambient temperature is described.
    Type: Grant
    Filed: March 21, 1996
    Date of Patent: March 24, 1998
    Assignee: Transcell Technologies, Inc.
    Inventors: Ramesh Kakarla, Michael J. Sofia
  • Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
    Patent number: 5693769
    Abstract: Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 2, 1997
    Assignees: Transcell Technologies, Inc., Trustees Of Princeton University
    Inventors: Daniel Evan Kahne, Suzanne Walker Kahne
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5693770
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
    Type: Grant
    Filed: June 23, 1995
    Date of Patent: December 2, 1997
    Assignee: Transcell Technologies, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz
  • Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
    Patent number: 5627270
    Abstract: Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: May 6, 1997
    Assignees: Trustees of Princeton University, Transcell Technologies, Inc.
    Inventors: Daniel E. Kahne, Suzanne W. Kahne, Michael J. Sofia, Nicole T. Hatzenbuhler
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5585470
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Novel intermediates and related compounds are also disclosed.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: December 17, 1996
    Assignee: Transcell Technologies, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz