Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.
Type:
Grant
Filed:
October 20, 2022
Date of Patent:
October 17, 2023
Assignee:
TranscripTx, Inc.
Inventors:
David J. Lockhart, Brandon Wustman, Mirko Hennig, Daniella Ishimaru
Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.
Type:
Grant
Filed:
July 28, 2020
Date of Patent:
May 9, 2023
Assignee:
TranscripTx, Inc.
Inventors:
David J. Lockhart, Brandon Wustman, Mirko Hennig, Daniella Ishimaru
Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with cilia maintenance and function, impaired function of the axoneme, such as DNAI1 or DNAH5.
Type:
Grant
Filed:
February 9, 2022
Date of Patent:
November 29, 2022
Assignee:
TranscripTx, Inc.
Inventors:
David J. Lockhart, Brandon Wustman, Mirko Hennig, Daniella Ishimaru
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