Abstract: Systems, devices, and methods for powering and/or controlling electrically powered devices. A power supply system is operable to provide a voltage across at the active and the counter electrode assemblies of a transdermal delivery device. The system includes a power source and a magnetic coupling element.

Abstract: An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.

Abstract: Systems, devices, and methods for transdermal delivery of one or more therapeutic active agents to a biological interface. An iontophoretic drug delivery system is provided for transdermal delivery of one or more therapeutic active agents to a biological interface of a subject. The iontophoretic drug delivery system includes at least one active agent reservoir. In some embodiments, the at least one active agent reservoir include a backbone modified hydrogel matrix for incorporation one or more active agents.

Abstract: An iontophoresis device includes an active electrode assembly including an active electrode element and at least one active agent reservoir. Active agents include one or more angiogenic growth factors suitable to promote or enhance healing or repair of injured or damaged tissue.

Abstract: An iontophoresis device includes active and counter electrode assemblies. The active electrode assembly includes an active electrode element and at least two laterally spaced active agent reservoirs. The active electrode assembly may also include an outermost ion selective membrane caching an active agent and a further active agent carried by an outer surface of the outermost ion selective membrane. The active electrode assembly may also include an electrolyte reservoir storing electrolyte and an inner ion selective membrane positioned between the electrolyte reservoir and the active agents. The active electrode may also include an inner withdrawable sealing liner between the electrolyte reservoir and the active agents. An outer release liner may protectively cover or overlay the further active agent and/or outer surface prior to use. The active electrode assembly may also include a blister pack of at least two hydrating agent blisters to selectively hydrate dehydrated active agent.

Abstract: Whether or not a prescribed active agent is properly used may be confirmed. Usage of an active agent to be administered by an active agent injecting device (such as an iontophoresis device) driven by a drive signal may managed through a server based on actual drive information from the active agent injecting device.

Abstract: Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and/or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.

Abstract: An iontophoresis device operable to deliver active agent to a biological interface such as skin or mucous membranes includes the combination of a hydrogel-based wound covering with an iontophoresis device to deliver antibiotic to biological interfaces. The effective concentration of antibiotics from oral or intravenous administration rarely reaches poorly perfused tissues such as cartilage or skin ulcerations resulting in entrenched and difficult to treat infections. Local deliver of additional antibiotic would serve to maintain the effective concentration of drug to the target tissues. Combining an iontophoresis device with a hydrogel-based wound covering to deliver localized antibiotic allows faster wound healing and prevent infection.

Abstract: An iontophoresis device is provided to delivery active agents to a biological interface, the iontophoresis device comprising: an active electrode element operable to provide an electrical potential; and an inner active agent reservoir comprising a plurality of nanoparticles, each nanoparticles being conjugated to a plurality of active agents via respective linkers.

Abstract: An iontophoresis device is provided for the delivery of active agents encapsulated in vesicles such as transferosomes and niosomes to a biological interface such as skin or mucous membranes.

Abstract: An active agent delivery device is operable to deliver an active agent such as a drug or therapeutic agent to a biological interface such as skin or mucous membrane. The device, such as an iontophoresis device, may include one or more human-perceptible indicators operable to provide an indication of a malfunction or other defective condition of the device. Detectors may be provided to detect a value of a characteristic or parameter associated with one or more components of the device, with the value being usable to determine whether a defective condition may exist.

Abstract: An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.

Abstract: An shaped iontophoresis device is capable of permeating an active agent (e.g., a drug solution) into an oral cavity, a skin cancer, or the like by iontophoresis in a pinpoint manner. A catheter-type iontophoresis device includes a small working electrode assembly and a small non-working electrode assembly at the tip of a holding portion. A first ion exchange membrane and a fourth ion exchange membrane at the tips of the assemblies are brought into close contact with a target area so that a drug solution is permeated by iontophoresis in a pinpoint manner. The working electrode assembly and the non-working electrode assembly 14 are attached to the tip of a rod-shaped member. The rod-shaped member is detachable from the tip of the holding portion, and is exchangeable integrally with the portion. The iontophoresis device may advantageously take the form of a rod or catheter.

Abstract: An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.

Abstract: One or more electrodes of an iontophoresis device may include a composite ion exchange membrane comprising a first ion exchange membrane of a first polarity and a second ion exchange membrane of a second polarity, or a first ion exchange membrane of the first polarity, a semi-permeable membrane, and a second ion exchange membrane of the second polarity. The respective membranes may be integrally coupled together. This may lead to simplified production processes, automated production, mass production, and reductions in production costs for the iontophoresis device.

Abstract: An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.

Abstract: A single electrolyte solution composition may be used in an anode side and in a cathode side of an iontophoresis device. The electrolyte solution may include a compound having an oxidation-reduction potential lower than that of water, the compound including, in combination, both a component that is likely to be relatively reduced and a component that is likely to be relatively oxidized.

Abstract: An iontophoresis device includes an active electrode assembly which comprises an active electrode element and an outermost active electrode ion selective membrane that caches an active agent. The outermost active electrode ion selective membrane may be formed by one or more ion exchange membranes. The active electrode assembly may also comprise an electrolyte and/or one or more inner active electrode ion selective membranes. The inner active electrode ion selective membrane may be a “leaky” ion selective membrane. The inner active electrode ion exchange membrane may be spaced from the outermost active electrode ion selective membrane, for example, by one or more non-ion selective porous membranes or by a buffer material and/or buffer reservoir. An iontophoresis device may also include a counter electrode assembly and/or voltage source.

Abstract: An iontophoresis device capable of administering a plurality of drugs to a living body while controlling the administration amounts and the administration periods thereof is described. The iontophoresis device may comprise: a power source device; a drug administration unit connected to the power source device and including at least two electrode structures that hold an ionic drug; and a current control unit that individually controls currents flowing to the electrode structures. A predetermined amount of the ionic drug may be released from each of the electrode structures to be administered transdermally to a living body in a predetermined period of time according to a current flowing from the current control unit.

Abstract: An iontophoresis device, and a control method thereof, may be capable of increasing movement speed of a drug into a living body and/or may be capable of administering a drug having a high molecular weight. The iontophoresis device may include an active electrode assembly comprising: a first electrode; a drug holding part that receives a current from the first electrode; and a first ion exchange membrane that selectively passes ions of a first polarity, the first ion exchange membrane being placed on a front side of the drug holding part. Drug ions of the first polarity generated by the dissociation of a drug held in the drug holding part may be administered to a living body through the first ion exchange membrane in contact with skin of the living body. The iontophoresis device may include heating means to heat the skin in contact with the first ion exchange membrane.