Patents Assigned to Transderm, Inc.
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Publication number: 20230278266Abstract: An active agent can be administered transdermally to a patient by using a transdermal patch that has microneedles that are compositionally homogenous with a base layer. The transdermal patch can contain an active agent that can be delivered to a skin surface of a subject when the patch is applied.Type: ApplicationFiled: November 9, 2022Publication date: September 7, 2023Applicant: TransDerm, Inc.Inventors: Roger L. KASPAR, Tycho Speaker
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Patent number: 10751032Abstract: A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.Type: GrantFiled: March 28, 2018Date of Patent: August 25, 2020Assignee: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Patent number: 10695548Abstract: The present invention is drawn to a low-cost “meso” device that is able to effectively deliver functional self-delivery siRNA to subject and inhibit expression of a gene in the subject as well as related methods. In particular, a method of transdermally delivering nucleic acid material to a subject is provided. The method includes adapting a motorized meso machine for delivery of nucleic acid material; introducing nucleic acid material into a chamber of the motorized meso machine; and contacting the motorized meso machine to a skin surface of a subject for a period of time sufficient to deliver the nucleic acid material into the skin surface of the subject.Type: GrantFiled: August 3, 2017Date of Patent: June 30, 2020Assignee: TRANSDERM, INC.Inventors: Roger L. Kaspar, Tycho Speaker
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Patent number: 10377062Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.Type: GrantFiled: February 4, 2013Date of Patent: August 13, 2019Assignee: TRANSDERM, INC.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20180345627Abstract: A moisture-responsive film can include a complexing substrate and an iodine layer applied to the complexing substrate to form the moisture-responsive film. The moisture-responsive film can include a test area formed on a testing surface of the moisture-responsive film.Type: ApplicationFiled: March 28, 2018Publication date: December 6, 2018Applicant: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20180001070Abstract: The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.Type: ApplicationFiled: May 8, 2017Publication date: January 4, 2018Applicant: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20170209553Abstract: A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.Type: ApplicationFiled: October 21, 2016Publication date: July 27, 2017Applicant: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20160263362Abstract: The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.Type: ApplicationFiled: June 30, 2015Publication date: September 15, 2016Applicant: TRANSDERM, INC.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20160256443Abstract: A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mTOR inhibitor to a subject afflicted with the hyperproliferation disorder. The mTOR inhibitor can be administered to the subject via any means known in the art including oral, topical, and transdermal administration.Type: ApplicationFiled: December 8, 2015Publication date: September 8, 2016Applicant: Transderm, Inc.Inventors: Roger Louis Kaspar, Robyn Patricia Hickerson
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Publication number: 20160184279Abstract: Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can include topically administering a therapeutically effective amount of an mTOR pathway inhibitor to the subject.Type: ApplicationFiled: December 10, 2015Publication date: June 30, 2016Applicant: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Patent number: 9205080Abstract: A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mTOR inhibitor to a subject afflicted with the hyperproliferation disorder. The mTOR inhibitor can be administered to the subject via any means known in the art including oral, topical, and transdermal administration.Type: GrantFiled: November 16, 2007Date of Patent: December 8, 2015Assignee: Transderm, Inc.Inventors: Roger Louis Kaspar, Robyn Patricia Hickerson
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Publication number: 20140315942Abstract: The present invention is drawn to formulations for the transdermal delivery of rapamycin or other related compounds. Specifically, in one embodiment a formulation for transdermally delivering rapamycin includes an mTOR inhibitor, such as rapamycin, water, a polymer having surfactant properties, a polymer having thickening properties, a solvent for solubilizing the mTOR inhibitor, a glycol, a C10-C20 fatty acid; and a base.Type: ApplicationFiled: January 24, 2014Publication date: October 23, 2014Applicant: TRANSDERM, INC.Inventors: Roger L. Kaspar, Tycho Speaker
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Publication number: 20140046262Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.Type: ApplicationFiled: February 4, 2013Publication date: February 13, 2014Applicant: TRANSDERM, INC.Inventor: Transderm, Inc.
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Publication number: 20130267916Abstract: Disclosed is a percutaneous absorption preparation for treatment of dementia that comprises rivastigmine or its pharmaceutically acceptable salt as an active ingredient, a styrene-isoprene-styrene block copolymer, a tackifier resin, and a plasticizer, which preparation contains a small amount of rivastigmine but allows a sufficient amount of the active ingredient penetrated into the skin to achieve an effective treatment of dementia.Type: ApplicationFiled: December 22, 2011Publication date: October 10, 2013Applicants: TRANSDERM INC., SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Hyun-Suk Yu, Young-Moo Lee, Hyun-Woo Kim, Hee-Sook Kim
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Patent number: 8530436Abstract: The present invention relates to formulations and related methods for transdermal delivery of nucleic acids. Specifically, the invention relates to a formulation containing lipids and an alcohol and which is capable of providing effective transdermal delivery of nucleic acid. The formulation can be used effectively to deliver nucleic acids for gene therapy and the treatment of disease.Type: GrantFiled: January 29, 2007Date of Patent: September 10, 2013Assignee: Transderm, Inc.Inventor: Roger Kaspar
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Patent number: 8476243Abstract: A method for keratin hyperproliferation disorders such as corns, calluses, or keratosis pilaris (KP) by administering to a subject experiencing the disorder a therapeutically effective amount of an RNA sequence which inhibits expression of a gene encoding for a keratin selected from the group consisting of K6a, K6b, K16, K17, and combinations thereof.Type: GrantFiled: December 29, 2006Date of Patent: July 2, 2013Assignee: Transderm, Inc.Inventors: Roger Louis Kaspar, Robyn Patricia Hickerson
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Patent number: 8366677Abstract: The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.Type: GrantFiled: August 6, 2008Date of Patent: February 5, 2013Assignee: Transderm, Inc.Inventors: Roger L. Kaspar, Tycho Speaker
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Patent number: 7723314Abstract: A method for treating pachyonychia congenita (PC) by identifying a genetic mutation contributing to PC, preparing a siRNA sequence that inhibits expression of the identified mutation, and administering the siRNA to a cell of a subject afflicted with PC. The siRNA treatment can include silencing of both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified.Type: GrantFiled: August 24, 2006Date of Patent: May 25, 2010Assignee: Transderm, Inc.Inventors: Roger L. Kaspar, Robyn P. Hickerson, Frances J. D. Smith, W. H. Irwin McLean